Безопасен ли trichosanthes kirilowii root extract при беременности?

Безопасные альтернативы trichosanthes kirilowii root extract при беременности | VeriMom

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Безопасен ли trichosanthes kirilowii root extract при беременности?

Animal and mechanistic data show trichosanthin (from T. kirilowii root) is embryotoxic/abortifacient and has been used clinically to induce abortion, so reproductive hazard is supported (h=2). The mechanism is demonstrated (ribosome‑inactivating protein with demonstrated abortion mechanisms in experimental studies), so m=2. For topical cosmetic use exposure is likely low but measurable (e=1) because extracts are applied topically and some dermal uptake or local activity is possible depending on formulation; however systemic exposure from typical cosmetic topical use is likely limited. ([pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/8102209/?utm_source=openai))

Безопасен ли trichosanthes kirilowii root extract при грудном вскармливании?

Because the same demonstrable reproductive/embryotoxic hazard exists for trichosanthin and systemic exposure (even small) could theoretically transfer into breastmilk, breastfeeding is flagged at the same hazard and mechanism level (h=2, m=2). Expected dermal/topical exposure is low but measurable (e=1); no direct data on lactational transfer from topical cosmetic use were found. ([pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/8102209/?utm_source=openai))

Безопасен ли trichosanthes kirilowii root extract для кожи малыша?

Hazard and mechanism are unchanged for infant skin (h=2, m=2) because the same toxic constituent (trichosanthin) is responsible. Exposure score is increased by +1 for baby skin to e=2 because infant skin has a higher surface‑area‑to‑weight ratio and less mature barrier, making dermal absorption and systemic exposure more likely from topical application of products containing the extract. No infant‑specific safety studies for topical T. kirilowii root extract were located. ([pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/8102209/?utm_source=openai))

Как VeriMom оценивает trichosanthes kirilowii root extract?

VeriMom оценивает trichosanthes kirilowii root extract в 40/100 (средний риск) на основе EU CosIng, классификаций ECHA и исследований PubMed.

Какие безопасные альтернативы trichosanthes kirilowii root extract при беременности?

См. наш список безопасных альтернатив trichosanthes kirilowii root extract с аналогичной функцией и классификацией без известных рисков.