Безопасен ли parthenolide при беременности?

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Frequently asked questions

Безопасен ли parthenolide при беременности?

No harmonised reproductive classification (no H360/H361 found) and no CIR/SCCS harmonised safety opinion flagging developmental or fertility hazards for parthenolide. Peer‑reviewed literature describes pharmacological activity (anti‑inflammatory/anticancer via NF‑κB) but does not provide clear animal or human developmental/teratogenic evidence that would raise the hazard score. Sources searched include ECHA C&L listings (no harmonised CLP), PubMed and general substance dossiers.

Безопасен ли parthenolide при грудном вскармливании?

No data located showing parthenolide causes reproductive or lactation-specific toxicity or a mechanistic basis for transfer into breastmilk in humans. Published studies focus on pharmacology/anticancer activity; no clinical or animal lactation-transfer studies were found that would justify raising the hazard, mechanism, or exposure scores.

Безопасен ли parthenolide для кожи малыша?

There is no infant‑specific toxicity evidence. Parthenolide is a small, lipophilic sesquiterpene lactone with demonstrated bioactivity in vitro/in vivo (pharmacology papers), so it is not completely non‑absorbable; per the scoring rules adult exposure default is 0 but baby exposure is increased by +1 to account for immature barrier and higher surface‑area‑to‑weight ratio. No infant dermal absorption studies were found to refine this estimate.

Как VeriMom оценивает parthenolide?

VeriMom оценивает parthenolide в 100/100 (без известных рисков) на основе EU CosIng, классификаций ECHA и исследований PubMed.

Какие безопасные альтернативы parthenolide при беременности?

См. наш список безопасных альтернатив parthenolide с аналогичной функцией и классификацией без известных рисков.