Безопасен ли n,n'-dimethyl-n-hydroxyethyl-3-nitro-p-phenylenediamine при беременности?

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Безопасен ли n,n'-dimethyl-n-hydroxyethyl-3-nitro-p-phenylenediamine при беременности?

No harmonised CLP reproductive classifications (H360/H361) or SCCS/CIR safety assessment specific to CAS 10228-03-2 were identified. Regulatory sources show this specific compound (N,N'-dimethyl-N-hydroxyethyl-3‑nitro-p‑phenylenediamine; CAS 10228-03-2) is listed in EU/Member‑state cosmetic prohibitions for use in hair‑dye products, but that listing does not equal a harmonised reproductive hazard classification; peer‑reviewed reproductive or developmental studies on this exact substance were not found. Dermal absorption data are available for the p‑phenylenediamine class (measurable but low percent systemic absorption in human/in vitro studies), so for topical use a low but measurable exposure is assigned. Sources: EU cosmetics annex/regulatory listings and dermal absorption studies of p‑phenylenediamine. (See sources.)

Безопасен ли n,n'-dimethyl-n-hydroxyethyl-3-nitro-p-phenylenediamine при грудном вскармливании?

Same rationale as pregnancy: no specific reproductive/breastmilk transfer or lactation studies for this CAS were found, no harmonised reproductive classification. Dermal exposure from cosmetic use of PPD‑type hair dyes is measurable; therefore a low but measurable exposure during breastfeeding is assigned in the absence of direct data. Regulatory prohibitions limit expected use in cosmetics in jurisdictions listing the CAS.

Безопасен ли n,n'-dimethyl-n-hydroxyethyl-3-nitro-p-phenylenediamine для кожи малыша?

No infant‑specific toxicology or dermal transfer data were found for CAS 10228-03-2. Following the scoring rules, because the adult exposure is judged low but measurable (e=1) and infants/0–3‑year skin has higher permeability and surface‑area‑to‑weight, exposure is increased by +1 (e=2). There is no direct evidence to increase hazard (h) or mechanism (m) for infants.

Как VeriMom оценивает n,n'-dimethyl-n-hydroxyethyl-3-nitro-p-phenylenediamine?

VeriMom оценивает n,n'-dimethyl-n-hydroxyethyl-3-nitro-p-phenylenediamine в 93/100 (без известных рисков) на основе EU CosIng, классификаций ECHA и исследований PubMed.

Какие безопасные альтернативы n,n'-dimethyl-n-hydroxyethyl-3-nitro-p-phenylenediamine при беременности?

См. наш список безопасных альтернатив n,n'-dimethyl-n-hydroxyethyl-3-nitro-p-phenylenediamine с аналогичной функцией и классификацией без известных рисков.