VeriMomБезопасен ли disodium glycyrrhizate при беременности?
No EU Annex II/III restriction or harmonised CLP classification for disodium glycyrrhizate was found, and CIR’s Final Report assessed disodium glycyrrhizate among licorice‑derived ingredients used in cosmetics and concluded safety in cosmetic use conditions. However, glycyrrhizic acid (parent molecule) has a demonstrated mechanism — inhibition of 11β‑HSD2 — producing mineralocorticoid effects and has been associated with adverse fetal/neonatal outcomes after maternal ingestion in epidemiological and animal studies; because this is a demonstrated endocrine mechanism it raises a suspected reproductive hazard for pregnancy when systemic exposure is possible. Sources: CIR final report (safety assessment covering disodium glycyrrhizate). Evidence of reproductive/foetal effects after oral licorice/glycyrrhizin exposure (epidemiology and animal studies). CosIng/EU ingredient listing supports cosmetic use but not a ban or restriction.
Безопасные альтернативы disodium glycyrrhizate при беременности | VeriMom
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- Безопасен ли disodium glycyrrhizate при беременности?
- No EU Annex II/III restriction or harmonised CLP classification for disodium glycyrrhizate was found, and CIR’s Final Report assessed disodium glycyrrhizate among licorice‑derived ingredients used in cosmetics and concluded safety in cosmetic use conditions. However, glycyrrhizic acid (parent molecule) has a demonstrated mechanism — inhibition of 11β‑HSD2 — producing mineralocorticoid effects and has been associated with adverse fetal/neonatal outcomes after maternal ingestion in epidemiological and animal studies; because this is a demonstrated endocrine mechanism it raises a suspected reproductive hazard for pregnancy when systemic exposure is possible. Sources: CIR final report (safety assessment covering disodium glycyrrhizate). Evidence of reproductive/foetal effects after oral licorice/glycyrrhizin exposure (epidemiology and animal studies). CosIng/EU ingredient listing supports cosmetic use but not a ban or restriction.
- Безопасен ли disodium glycyrrhizate при грудном вскармливании?
- Mechanistic evidence (11β‑HSD2 inhibition by glycyrrhizic acid) is demonstrated and oral maternal intake of glycyrrhizin can lead to systemic effects; this supports a suspected hazard for breastfeeding if maternal systemic exposure is significant. Topical cosmetic use is expected to give low systemic absorption, so breastfeeding exposure from cosmetic topical use is likely low (measurable but small). CIR assessed cosmetic salts (including disodium glycyrrhizate) as safe as used; no harmonised CLP or EU ban/restriction was found.
- Безопасен ли disodium glycyrrhizate для кожи малыша?
- No harmonised classification or EU ban/restriction for disodium glycyrrhizate; CIR concluded cosmetic use is acceptable. The parent molecule has a demonstrated mechanism (11β‑HSD2 inhibition), so a mechanistic flag exists. For topical use on infant skin, absorption is higher (immature barrier and higher surface‑area‑to‑weight) so exposure score is increased; however there is no direct infant dermal reproductive/toxicology data showing harm from cosmetic topical use. Therefore hazard is scored as 1 (class/mechanistic concern present but no direct dermal reproductive evidence for the cosmetic salt).
- Как VeriMom оценивает disodium glycyrrhizate?
- VeriMom оценивает disodium glycyrrhizate в 40/100 (средний риск) на основе EU CosIng, классификаций ECHA и исследований PubMed.
- Какие безопасные альтернативы disodium glycyrrhizate при беременности?
- См. наш список безопасных альтернатив disodium glycyrrhizate с аналогичной функцией и классификацией без известных рисков.
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Медицинская оговорка
Данная информация предоставлена исключительно в образовательных целях и не является медицинской рекомендацией. Оценки безопасности основаны на общедоступных данных и могут не отражать все риски. Всегда консультируйтесь с вашим врачом перед использованием любых средств во время беременности или грудного вскармливания.