Безопасен ли cis-3,5,5-trimethylcyclohexanol при беременности?

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Frequently asked questions

Безопасен ли cis-3,5,5-trimethylcyclohexanol при беременности?

No harmonised CLP reproductive classification or SCCS/CIR safety assessment was found for cis-3,3,5‑trimethylcyclohexanol (CAS 933‑48‑2). PubMed/PMC pharmacokinetic/metabolism studies show the substance is absorbed/metabolised (glucuronidation in rat hepatocytes), indicating low but measurable systemic exposure after absorption, so exposure (e) is scored 1. Sources searched show hepatic/metabolism studies but no reproductive or teratogenic data. (See PubMed/PMC and ECHA registration data.)

Безопасен ли cis-3,5,5-trimethylcyclohexanol при грудном вскармливании?

No evidence of reproductive or lactation-specific toxicity or human teratogenicity was identified in the literature or in ECHA registration records. Metabolism data (rat hepatocytes; glucuronide formation) indicate the compound can be systemically available after absorption, so breastfeeding exposure is scored as low but measurable (e=1). No studies reporting transfer into milk or effects on nursing infants were found.

Безопасен ли cis-3,5,5-trimethylcyclohexanol для кожи малыша?

No infant-specific toxicity or developmental effects were identified. Because (a) the compound shows measurable uptake/metabolism in in vitro/in vivo models (rats/hepatocytes) and (b) infant skin has higher absorption per body weight, I increased exposure for baby skin by +1 (adult e=1 → baby e=2). There is no evidence to increase hazard (h) or mechanism (m) for infants in available studies.

Как VeriMom оценивает cis-3,5,5-trimethylcyclohexanol?

VeriMom оценивает cis-3,5,5-trimethylcyclohexanol в 93/100 (без известных рисков) на основе EU CosIng, классификаций ECHA и исследований PubMed.

Какие безопасные альтернативы cis-3,5,5-trimethylcyclohexanol при беременности?

См. наш список безопасных альтернатив cis-3,5,5-trimethylcyclohexanol с аналогичной функцией и классификацией без известных рисков.