VeriMomБезопасен ли capryloyl salicylic acid при беременности?
Animal developmental data show effects at high doses (dermal application in pregnant rats: increased incomplete ossification at 100 mg/kg/day; NOAEL for developmental toxicity 40 mg/kg/day), so reproductive/developmental hazard is suspected based on animal evidence; there is no harmonised CLP reproductive classification and CIR concluded cosmetic use at reported concentrations is safe. Dermal absorption in vitro is low but measurable (~6% penetrated deeper than the stratum corneum in a 16 h Franz cell study), so exposure from typical topical cosmetic use is low but measurable.
Безопасные альтернативы capryloyl salicylic acid при беременности | VeriMom
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Frequently asked questions
- Безопасен ли capryloyl salicylic acid при беременности?
- Animal developmental data show effects at high doses (dermal application in pregnant rats: increased incomplete ossification at 100 mg/kg/day; NOAEL for developmental toxicity 40 mg/kg/day), so reproductive/developmental hazard is suspected based on animal evidence; there is no harmonised CLP reproductive classification and CIR concluded cosmetic use at reported concentrations is safe. Dermal absorption in vitro is low but measurable (~6% penetrated deeper than the stratum corneum in a 16 h Franz cell study), so exposure from typical topical cosmetic use is low but measurable.
- Безопасен ли capryloyl salicylic acid при грудном вскармливании?
- No direct data on excretion in milk were identified; because animal developmental effects exist (see pregnancy section) the ingredient is treated as a suspected reproductive/developmental hazard. Maternal topical exposure gives low but measurable dermal penetration (CIR data), so systemic exposure cannot be excluded though milk transfer data are absent.
- Безопасен ли capryloyl salicylic acid для кожи малыша?
- Do not increase hazard without infant-specific evidence; however exposure score is increased by +1 for infants because CIR reports measurable dermal penetration in adults (~6% beyond stratum corneum and ~17% in stratum corneum by tape‑strip), and infant skin has higher absorption per weight. There are no infant-specific safety studies; CIR considered cosmetic uses (max reported leave‑on 0.5%) acceptable given available data.
- Как VeriMom оценивает capryloyl salicylic acid?
- VeriMom оценивает capryloyl salicylic acid в 53/100 (средний риск) на основе EU CosIng, классификаций ECHA и исследований PubMed.
- Какие безопасные альтернативы capryloyl salicylic acid при беременности?
- См. наш список безопасных альтернатив capryloyl salicylic acid с аналогичной функцией и классификацией без известных рисков.
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Медицинская оговорка
Данная информация предоставлена исключительно в образовательных целях и не является медицинской рекомендацией. Оценки безопасности основаны на общедоступных данных и могут не отражать все риски. Всегда консультируйтесь с вашим врачом перед использованием любых средств во время беременности или грудного вскармливания.