Безопасен ли bis-acryloyl poloxamer 407 при беременности?

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Безопасен ли bis-acryloyl poloxamer 407 при беременности?

No regulatory ban/restriction (EU Annex II/III) or harmonised CLP reproductive classification found for bis‑acryloyl poloxamer 407 or poloxamer 407; no peer‑reviewed reproductive/developmental studies located for the bis‑acryloyl derivative. The parent (poloxamer 407) is a large non‑ionic polymer with generally low systemic toxicity, and the acrylated derivative is used as a high‑MW film former. Theoretical mechanism concern is the acrylate functionality (reactive monomer residues), not a demonstrated reproductive mechanism. ([echa.europa.eu](https://echa.europa.eu/et/substance-information/-/substanceinfo/100.122.042?utm_source=openai))

Безопасен ли bis-acryloyl poloxamer 407 при грудном вскармливании?

Same rationale as pregnancy: no evidence of harmonised reproductive or lactation hazard and no SCCS/CIR safety assessment specific to the bis‑acryloyl derivative was found. Mechanistic plausibility relates to potential residual acrylate monomer (reactive), but no data show placental/lactational transfer or reproductive effects for this ingredient as used in cosmetics. ([cir-safety.org](https://www.cir-safety.org/ingredient/poloxamer-407?utm_source=openai))

Безопасен ли bis-acryloyl poloxamer 407 для кожи малыша?

No baby‑specific toxicity or harmonised classifications located. Exposure concern is increased for infants because their skin barrier is thinner — although the ingredient is a high‑MW polymer expected to act on the skin surface, infant exposure is considered higher (+1) by the scoring rules if there is measurable absorption potential. Mechanistic note: potential hazard derives from acrylate residues, not from the large polymer itself; no infant reproductive or developmental data were found. ([glooshi.com](https://www.glooshi.com/bis-acryloyl-poloxamer-407/?utm_source=openai))

Как VeriMom оценивает bis-acryloyl poloxamer 407?

VeriMom оценивает bis-acryloyl poloxamer 407 в 93/100 (без известных рисков) на основе EU CosIng, классификаций ECHA и исследований PubMed.

Какие безопасные альтернативы bis-acryloyl poloxamer 407 при беременности?

См. наш список безопасных альтернатив bis-acryloyl poloxamer 407 с аналогичной функцией и классификацией без известных рисков.