VeriMomБезопасен ли ammonium glycyrrhizate при беременности?
CIR’s final safety assessment includes ammonium glycyrrhizate and judges cosmetic use acceptable with typical use conditions, but independent human/epidemiological and toxicology assessments link glycyrrhizic/glycyrrhetinic acids (parent compounds) with pregnancy outcomes after oral exposure via inhibition of placental 11β‑HSD2 and associated fetal effects; therefore reproductive concern is suspected (h=2) with a demonstrated mechanism (m=2). For topical cosmetic use systemic absorption is expected to be low but measurable, so exposure score is 1. (Sources: CIR final report; VKM risk assessment; PBPK and human studies summarized in LactMed and literature).
Безопасные альтернативы ammonium glycyrrhizate при беременности | VeriMom
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Frequently asked questions
- Безопасен ли ammonium glycyrrhizate при беременности?
- CIR’s final safety assessment includes ammonium glycyrrhizate and judges cosmetic use acceptable with typical use conditions, but independent human/epidemiological and toxicology assessments link glycyrrhizic/glycyrrhetinic acids (parent compounds) with pregnancy outcomes after oral exposure via inhibition of placental 11β‑HSD2 and associated fetal effects; therefore reproductive concern is suspected (h=2) with a demonstrated mechanism (m=2). For topical cosmetic use systemic absorption is expected to be low but measurable, so exposure score is 1. (Sources: CIR final report; VKM risk assessment; PBPK and human studies summarized in LactMed and literature).
- Безопасен ли ammonium glycyrrhizate при грудном вскармливании?
- Glycyrrhizic acid (parent) has been detected in breastmilk after maternal oral intake and systemic effects are reported with ingestion; mechanism (11β‑HSD2 inhibition and systemic glycyrrhetinic metabolites) is demonstrated. For topical cosmetic use transfer to milk from topical use is unlikely but possible at low measurable levels, so exposure =1 and hazard =2 pending significant systemic exposure. (Sources: LactMed/NCBI; CIR; VKM).
- Безопасен ли ammonium glycyrrhizate для кожи малыша?
- No infant‑specific topical hazard data found; hazard and mechanism remain linked to the parent glycyrrhizic/glycyrrhetinic acids (h=2, m=2). Because infant skin has higher per‑kg absorption, raise exposure by +1 compared with adults (adult e=1 → infant e=2) when the ingredient shows measurable absorption. No evidence supports increasing hazard or mechanism scores for infants in the absence of infant‑specific toxicology. (Sources: CIR; VKM; LactMed).
- Как VeriMom оценивает ammonium glycyrrhizate?
- VeriMom оценивает ammonium glycyrrhizate в 40/100 (средний риск) на основе EU CosIng, классификаций ECHA и исследований PubMed.
- Какие безопасные альтернативы ammonium glycyrrhizate при беременности?
- См. наш список безопасных альтернатив ammonium glycyrrhizate с аналогичной функцией и классификацией без известных рисков.
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Медицинская оговорка
Данная информация предоставлена исключительно в образовательных целях и не является медицинской рекомендацией. Оценки безопасности основаны на общедоступных данных и могут не отражать все риски. Всегда консультируйтесь с вашим врачом перед использованием любых средств во время беременности или грудного вскармливания.