VeriMomБезопасен ли allyl succinic anhydride при беременности?
No harmonised CLP reproductive classifications, no SCCS/CIR safety assessment, and no peer‑reviewed reproductive or developmental toxicity data were found for allyl succinic anhydride (3‑allyl(dihydro)furan‑2,5‑dione, CAS 7539‑12‑0). Regulatory listings (ECHA PACT / substance pages) do not show a harmonised H360/H361 classification. Acute and irritation data indicate it is a skin/eye irritant and has measurable dermal toxicity (SDS reports dermal LD50 ≈320 mg/kg), so some dermal absorption is plausible with typical topical use — therefore exposure (e) is scored 1 for adults. (Sources: PubChem entry https://pubchem.ncbi.nlm.nih.gov/compound/111009; ECHA listing/PACT entries; manufacturer SDS https://www.gelest.com/wp-content/uploads/product_msds/ENEA0430-msds.pdf).
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Frequently asked questions
- Безопасен ли allyl succinic anhydride при беременности?
- No harmonised CLP reproductive classifications, no SCCS/CIR safety assessment, and no peer‑reviewed reproductive or developmental toxicity data were found for allyl succinic anhydride (3‑allyl(dihydro)furan‑2,5‑dione, CAS 7539‑12‑0). Regulatory listings (ECHA PACT / substance pages) do not show a harmonised H360/H361 classification. Acute and irritation data indicate it is a skin/eye irritant and has measurable dermal toxicity (SDS reports dermal LD50 ≈320 mg/kg), so some dermal absorption is plausible with typical topical use — therefore exposure (e) is scored 1 for adults. (Sources: PubChem entry https://pubchem.ncbi.nlm.nih.gov/compound/111009; ECHA listing/PACT entries; manufacturer SDS https://www.gelest.com/wp-content/uploads/product_msds/ENEA0430-msds.pdf).
- Безопасен ли allyl succinic anhydride при грудном вскармливании?
- There is no evidence of reproductive or lactation-specific toxicity or breast‑milk transfer data in the literature or regulatory dossiers for this substance; no SCCS/CIR opinion was identified. Because the compound is an anhydride that can hydrolyse and manufacturer SDSs report dermal toxicity/irritation, low but measurable dermal absorption is possible, so adult exposure is scored 1. (Sources: PubChem https://pubchem.ncbi.nlm.nih.gov/compound/111009; Gelest SDS https://www.gelest.com/wp-content/uploads/product_msds/ENEA0430-msds.pdf; ECHA listings).
- Безопасен ли allyl succinic anhydride для кожи малыша?
- No infant-specific reproductive or toxicity data were identified. Per the scoring rules, because adult topical exposure is judged low but measurable (e=1) and available data show skin irritation/dermal toxicity (SDS), baby skin exposure is increased by +1 to e=2 due to immature barrier and higher surface‑area‑to‑weight; hazard and mechanism are unchanged in absence of infant‑specific evidence. (Sources: Gelest SDS https://www.gelest.com/wp-content/uploads/product_msds/ENEA0430-msds.pdf; PubChem https://pubchem.ncbi.nlm.nih.gov/compound/111009).
- Как VeriMom оценивает allyl succinic anhydride?
- VeriMom оценивает allyl succinic anhydride в 93/100 (без известных рисков) на основе EU CosIng, классификаций ECHA и исследований PubMed.
- Какие безопасные альтернативы allyl succinic anhydride при беременности?
- См. наш список безопасных альтернатив allyl succinic anhydride с аналогичной функцией и классификацией без известных рисков.
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Медицинская оговорка
Данная информация предоставлена исключительно в образовательных целях и не является медицинской рекомендацией. Оценки безопасности основаны на общедоступных данных и могут не отражать все риски. Всегда консультируйтесь с вашим врачом перед использованием любых средств во время беременности или грудного вскармливания.