Стоит ли избегать thiabendazole при беременности? | VeriMom

What to use instead

Pregnancy-safe ingredients that serve a similar function:

FAQ

Безопасен ли thiabendazole при беременности?

Thiabendazole has an EU harmonised classification that includes reproductive toxicity H360 (Category 1B / H360FD in CLP listings), which meets criteria for confirmed reproductive hazard. ECHA/CLP documents and the EU delegated regulation list H360 for thiabendazole, and multiple developmental/reproductive animal studies (rats, mice, rabbits) and JECFA/WHO monographs report fetal and developmental effects at toxic doses, supporting demonstrable mechanism(s) of developmental toxicity and systemic distribution. Sources: ECHA substance/factsheet and EU CLP entry; peer-reviewed developmental studies and JECFA monographs.

Безопасен ли thiabendazole при грудном вскармливании?

Because of the harmonised H360 classification and animal/peer-reviewed data showing systemic absorption and distribution (including to fetal tissues) and developmental effects, thiabendazole is flagged for reproductive/developmental hazard that is relevant to lactation exposure. Human/animal ADME data show rapid absorption and systemic distribution; lactational transfer is plausible though milk-specific data are limited, so exposure to breastfed infants is considered low but measurable from systemic maternal exposure.

Безопасен ли thiabendazole для кожи малыша?

Hazard and mechanism are not increased for infants absent infant‑specific hazard evidence, but the harmonised H360 classification and animal developmental findings indicate a high reproductive/developmental hazard. Dermal/topical exposure on baby skin is assigned a higher exposure score (+1) because infant skin has higher surface-area-to-weight and an immature barrier and thiabendazole has measurable systemic absorption in ADME studies, so topical use could give measurable systemic exposure in infants.

Как VeriMom оценивает thiabendazole?

VeriMom оценивает thiabendazole в 20/100 (высокий риск) на основе EU CosIng, классификаций ECHA и исследований PubMed.

Какие безопасные альтернативы thiabendazole при беременности?

См. наш список безопасных альтернатив thiabendazole с аналогичной функцией и классификацией без известных рисков.