Стоит ли избегать theophylline при беременности? | VeriMom

What to use instead

Pregnancy-safe ingredients that serve a similar function:

FAQ

Безопасен ли theophylline при беременности?

Animal studies (mouse continuous-breeding, NTP/NIEHS; and rabbit developmental studies) report reduced pup numbers, fetal effects and teratogenicity at high systemic doses, supporting a suspected reproductive/developmental hazard. Theophylline crosses the placenta in humans/animals (demonstrated placental transfer). For topical cosmetic use maternal systemic exposure is likely low but measurable, so exposure to the fetus from maternal use is possible but expected to be limited. (Sources: NTP reproductive study; rabbit teratogenicity study; pharmacokinetic/label notes on placental transfer).

Безопасен ли theophylline при грудном вскармливании?

Theophylline is known to be excreted into human breast milk and neonatal effects have been reported following maternal administration; animal reproductive/developmental evidence also exists. Mechanistic evidence includes demonstrated transfer into milk. For topical cosmetic use maternal systemic uptake is likely low but measurable so infant exposure via milk is possible but expected to be limited for cosmetic use.

Безопасен ли theophylline для кожи малыша?

Animal data indicate reproductive/developmental toxicity at systemic doses; theophylline also crosses biological barriers (placenta, milk) indicating demonstrated distribution. Infant skin (0–3 yr) has higher dermal uptake per surface-area-to-weight; therefore exposure (e) is increased by +1 versus adults when the ingredient has measurable absorption. There is no infant-specific data showing a different hazard classification, but systemic developmental/neurologic concerns from theophylline support a suspected hazard for infants if systemic exposure occurs.

Как VeriMom оценивает theophylline?

VeriMom оценивает theophylline в 20/100 (высокий риск) на основе EU CosIng, классификаций ECHA и исследований PubMed.

Какие безопасные альтернативы theophylline при беременности?

См. наш список безопасных альтернатив theophylline с аналогичной функцией и классификацией без известных рисков.