VeriMomСтоит ли избегать retinyl propionate при беременности? | VeriMom
Animal and toxicology literature show that preformed vitamin A and retinoids (including retinyl esters) cause dose‑dependent embryofetal malformations in multiple species; expert panels (CIR, SCCS) have reviewed retinol/retinyl esters for cosmetics. ECHA/industry dossiers and supplier SDSs list reproductive hazard statements (H360/H361) as self‑classified for retinyl propionate, and animal data (e.g., rodent/macaque studies of retinyl esters/retinoic acid) demonstrate teratogenicity. Topical cosmetic use gives low but measurable dermal absorption, so systemic exposure is generally low but not zero. Sources: CIR (retinol/retinyl esters safety assessment), SCCS opinions on vitamin A, ECHA registration / supplier SDSs, peer‑reviewed animal teratogenicity studies.
ECHA regulatory hazard statements
- •H360
- •H361d
What to use instead
Pregnancy-safe ingredients that serve a similar function:
FAQ
- Безопасен ли retinyl propionate при беременности?
- Animal and toxicology literature show that preformed vitamin A and retinoids (including retinyl esters) cause dose‑dependent embryofetal malformations in multiple species; expert panels (CIR, SCCS) have reviewed retinol/retinyl esters for cosmetics. ECHA/industry dossiers and supplier SDSs list reproductive hazard statements (H360/H361) as self‑classified for retinyl propionate, and animal data (e.g., rodent/macaque studies of retinyl esters/retinoic acid) demonstrate teratogenicity. Topical cosmetic use gives low but measurable dermal absorption, so systemic exposure is generally low but not zero. Sources: CIR (retinol/retinyl esters safety assessment), SCCS opinions on vitamin A, ECHA registration / supplier SDSs, peer‑reviewed animal teratogenicity studies.
- Безопасен ли retinyl propionate при грудном вскармливании?
- Mechanism (retinoid activity) is the same and systemic exposure from topical use is low but measurable; transferred levels in breastmilk after topical cosmetic use are not well quantified. Given the known developmental effects of systemic retinoids, breastfeeding risk is considered linked to maternal systemic exposure (which for cosmetic topical use is generally low). Relevant sources: CIR, SCCS, ECHA dossiers/SDS, animal/developmental literature.
- Безопасен ли retinyl propionate для кожи малыша?
- No infant‑specific developmental hazard data were located; however, retinyl propionate is a retinol ester metabolised to active retinoids (mechanistic concern). Infant skin has higher absorption (immature barrier, higher surface‑area‑to‑weight), so exposure score is increased by +1. There is a lack of infant dermal PK data for retinyl propionate specifically. Sources: CIR and SCCS reviews of retinol/retinyl esters; general toxicology literature on retinoid embryopathy; ECHA registration/SDS noting reproductive hazard classifications.
- Как VeriMom оценивает retinyl propionate?
- VeriMom оценивает retinyl propionate в 13/100 (высокий риск) на основе EU CosIng, классификаций ECHA и исследований PubMed.
- Какие безопасные альтернативы retinyl propionate при беременности?
- См. наш список безопасных альтернатив retinyl propionate с аналогичной функцией и классификацией без известных рисков.
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Медицинская оговорка
Данная информация предоставлена исключительно в образовательных целях и не является медицинской рекомендацией. Оценки безопасности основаны на общедоступных данных и могут не отражать все риски. Всегда консультируйтесь с вашим врачом перед использованием любых средств во время беременности или грудного вскармливания.