VeriMomСтоит ли избегать oxyquinoline при беременности? | VeriMom
Quinolin-8-ol (oxyquinoline, CAS 148-24-3) has an EU harmonised classification as a reproductive toxicant (Repr. 1B — H360D: “may damage the unborn child”), which by your scoring rules requires h=3. Mechanistic data linking a specific reproductive pathway are limited (mutagenicity was reported in some assays but no well‑characterised developmental mechanism), so m is scored 1 (theoretical/limited). For typical topical cosmetic use (used at ≤1% in formulations per CIR), dermal uptake is plausible but not high, so exposure (e) for pregnancy is scored 1 (low but measurable). (Sources: ECHA/EUR‑Lex harmonised classification; CIR safety assessment.).
ECHA regulatory hazard statements
- •H360D
What to use instead
Pregnancy-safe ingredients that serve a similar function:
FAQ
- Безопасен ли oxyquinoline при беременности?
- Quinolin-8-ol (oxyquinoline, CAS 148-24-3) has an EU harmonised classification as a reproductive toxicant (Repr. 1B — H360D: “may damage the unborn child”), which by your scoring rules requires h=3. Mechanistic data linking a specific reproductive pathway are limited (mutagenicity was reported in some assays but no well‑characterised developmental mechanism), so m is scored 1 (theoretical/limited). For typical topical cosmetic use (used at ≤1% in formulations per CIR), dermal uptake is plausible but not high, so exposure (e) for pregnancy is scored 1 (low but measurable). (Sources: ECHA/EUR‑Lex harmonised classification; CIR safety assessment.).
- Безопасен ли oxyquinoline при грудном вскармливании?
- Because the substance has a harmonised Repr.1B/H360D classification (systemic reproductive hazard), the hazard to nursing is scored h=3 under your rules. There is no clear, well‑established mechanism specific to lactational transfer (m=1). Dermal cosmetic use gives low but potentially measurable systemic exposure (e=1), so transfer into milk cannot be excluded at trace levels; no robust human milk data were found in the reviewed sources.
- Безопасен ли oxyquinoline для кожи малыша?
- Do not increase hazard or mechanism absent infant‑specific data, so h=3 and m=1 as above. Because infant skin has higher permeability and surface‑area‑to‑weight, exposure score is increased by +1 from adult (adult e=1 → infant e=2), meaning moderate concern for systemic uptake from topical application to infant skin. No infant‑specific toxicokinetic or outcome studies were identified.
- Как VeriMom оценивает oxyquinoline?
- VeriMom оценивает oxyquinoline в 27/100 (высокий риск) на основе EU CosIng, классификаций ECHA и исследований PubMed.
- Какие безопасные альтернативы oxyquinoline при беременности?
- См. наш список безопасных альтернатив oxyquinoline с аналогичной функцией и классификацией без известных рисков.
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Медицинская оговорка
Данная информация предоставлена исключительно в образовательных целях и не является медицинской рекомендацией. Оценки безопасности основаны на общедоступных данных и могут не отражать все риски. Всегда консультируйтесь с вашим врачом перед использованием любых средств во время беременности или грудного вскармливания.