VeriMompaeonol est-il sûr pendant la grossesse ?
No EU Annex II/III listing or harmonised reproductive (H360/H361) classification was found for paeonol (ECHA substance page). The CIR safety assessment of Paeonia-derived ingredients (which identifies paeonol as a major constituent) did not identify reproductive/developmental hazards and concluded data were insufficient to make safety determinations for most extracts rather than finding a reproductive hazard (CIR, Dec 13, 2024). Limited animal/experimental reports show tissue distribution to uterus after oral dosing in mice but do not demonstrate developmental toxicity (PubMed). Therefore hazard (h) is 0; a low but measurable topical absorption is plausible so exposure (e) is 1. Sources: https://www.cir-safety.org/sites/default/files/TR_PaeoniaSuffruticosa_122024.pdf, https://pubmed.ncbi.nlm.nih.gov/32058234/, https://echa.europa.eu/substance-information/-/substanceinfo/100.008.194
Pregnancy-safe products containing paeonol
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Frequently asked questions
- paeonol est-il sûr pendant la grossesse ?
- No EU Annex II/III listing or harmonised reproductive (H360/H361) classification was found for paeonol (ECHA substance page). The CIR safety assessment of Paeonia-derived ingredients (which identifies paeonol as a major constituent) did not identify reproductive/developmental hazards and concluded data were insufficient to make safety determinations for most extracts rather than finding a reproductive hazard (CIR, Dec 13, 2024). Limited animal/experimental reports show tissue distribution to uterus after oral dosing in mice but do not demonstrate developmental toxicity (PubMed). Therefore hazard (h) is 0; a low but measurable topical absorption is plausible so exposure (e) is 1. Sources: https://www.cir-safety.org/sites/default/files/TR_PaeoniaSuffruticosa_122024.pdf, https://pubmed.ncbi.nlm.nih.gov/32058234/, https://echa.europa.eu/substance-information/-/substanceinfo/100.008.194
- paeonol est-il sûr pendant l'allaitement ?
- No data were located indicating paeonol is a known lactation teratogen or has harmonised reproductive/lactation classification (ECHA; CIR). There are reports that whole peony preparations can affect prolactin, but these refer to other peony constituents (paeoniflorin) and not paeonol specifically (LactMed/peony summaries). Given limited systemic exposure from typical topical cosmetic use, exposure via milk is expected to be low but measurable (h=0, e=1). Sources: https://www.cir-safety.org/sites/default/files/TR_PaeoniaSuffruticosa_122024.pdf, https://www.ncbi.nlm.nih.gov/books/NBK501902/, https://echa.europa.eu/substance-information/-/substanceinfo/100.008.194
- paeonol est-il sûr pour la peau de bébé ?
- No evidence specific to infants (0–3 yr) shows developmental or reproductive hazard for paeonol and no harmonised CMR classification exists (ECHA; CIR). However, because paeonol is a small phenolic molecule used topically and dermal absorption is plausible, infant exposure is higher due to immature barrier and higher surface-area-to-weight; per scoring rules exposure is increased by +1 (adult e=1 → baby e=2). No infant-specific mechanistic evidence was found. Sources: https://www.cir-safety.org/sites/default/files/TR_PaeoniaSuffruticosa_122024.pdf, https://echa.europa.eu/substance-information/-/substanceinfo/100.008.194, https://pubmed.ncbi.nlm.nih.gov/32058234/
- Comment VeriMom évalue-t-il paeonol ?
- VeriMom évalue paeonol à 93/100 (pas de risques connus) sur la base du statut EU CosIng, des classifications ECHA et des études PubMed.
- Quelles sont les alternatives sûres à paeonol pendant la grossesse ?
- Consultez notre liste d'alternatives sûres à paeonol basée sur une fonction similaire et une classification sans risques connus.
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Avis Médical
Ces informations sont fournies à titre éducatif uniquement et ne constituent pas un avis médical. Les scores de sécurité sont basés sur des données accessibles au public et peuvent ne pas refléter tous les risques. Consultez toujours votre professionnel de santé avant d'utiliser tout produit pendant la grossesse ou l'allaitement.