VeriMomdisodium glycyrrhizate est-il sûr pendant la grossesse ?
No EU Annex II/III restriction or harmonised CLP classification for disodium glycyrrhizate was found, and CIR’s Final Report assessed disodium glycyrrhizate among licorice‑derived ingredients used in cosmetics and concluded safety in cosmetic use conditions. However, glycyrrhizic acid (parent molecule) has a demonstrated mechanism — inhibition of 11β‑HSD2 — producing mineralocorticoid effects and has been associated with adverse fetal/neonatal outcomes after maternal ingestion in epidemiological and animal studies; because this is a demonstrated endocrine mechanism it raises a suspected reproductive hazard for pregnancy when systemic exposure is possible. Sources: CIR final report (safety assessment covering disodium glycyrrhizate). Evidence of reproductive/foetal effects after oral licorice/glycyrrhizin exposure (epidemiology and animal studies). CosIng/EU ingredient listing supports cosmetic use but not a ban or restriction.
Alternatives sûres à disodium glycyrrhizate pendant la grossesse | VeriMom
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Frequently asked questions
- disodium glycyrrhizate est-il sûr pendant la grossesse ?
- No EU Annex II/III restriction or harmonised CLP classification for disodium glycyrrhizate was found, and CIR’s Final Report assessed disodium glycyrrhizate among licorice‑derived ingredients used in cosmetics and concluded safety in cosmetic use conditions. However, glycyrrhizic acid (parent molecule) has a demonstrated mechanism — inhibition of 11β‑HSD2 — producing mineralocorticoid effects and has been associated with adverse fetal/neonatal outcomes after maternal ingestion in epidemiological and animal studies; because this is a demonstrated endocrine mechanism it raises a suspected reproductive hazard for pregnancy when systemic exposure is possible. Sources: CIR final report (safety assessment covering disodium glycyrrhizate). Evidence of reproductive/foetal effects after oral licorice/glycyrrhizin exposure (epidemiology and animal studies). CosIng/EU ingredient listing supports cosmetic use but not a ban or restriction.
- disodium glycyrrhizate est-il sûr pendant l'allaitement ?
- Mechanistic evidence (11β‑HSD2 inhibition by glycyrrhizic acid) is demonstrated and oral maternal intake of glycyrrhizin can lead to systemic effects; this supports a suspected hazard for breastfeeding if maternal systemic exposure is significant. Topical cosmetic use is expected to give low systemic absorption, so breastfeeding exposure from cosmetic topical use is likely low (measurable but small). CIR assessed cosmetic salts (including disodium glycyrrhizate) as safe as used; no harmonised CLP or EU ban/restriction was found.
- disodium glycyrrhizate est-il sûr pour la peau de bébé ?
- No harmonised classification or EU ban/restriction for disodium glycyrrhizate; CIR concluded cosmetic use is acceptable. The parent molecule has a demonstrated mechanism (11β‑HSD2 inhibition), so a mechanistic flag exists. For topical use on infant skin, absorption is higher (immature barrier and higher surface‑area‑to‑weight) so exposure score is increased; however there is no direct infant dermal reproductive/toxicology data showing harm from cosmetic topical use. Therefore hazard is scored as 1 (class/mechanistic concern present but no direct dermal reproductive evidence for the cosmetic salt).
- Comment VeriMom évalue-t-il disodium glycyrrhizate ?
- VeriMom évalue disodium glycyrrhizate à 40/100 (risque moyen) sur la base du statut EU CosIng, des classifications ECHA et des études PubMed.
- Quelles sont les alternatives sûres à disodium glycyrrhizate pendant la grossesse ?
- Consultez notre liste d'alternatives sûres à disodium glycyrrhizate basée sur une fonction similaire et une classification sans risques connus.
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Avis Médical
Ces informations sont fournies à titre éducatif uniquement et ne constituent pas un avis médical. Les scores de sécurité sont basés sur des données accessibles au public et peuvent ne pas refléter tous les risques. Consultez toujours votre professionnel de santé avant d'utiliser tout produit pendant la grossesse ou l'allaitement.