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Dois-je éviter styrene oxide pendant la grossesse ? | VeriMom

Styrene oxide (CAS 96-09-3) has a harmonised CLP classification in the EU including Carc. 1B (H350: “May cause cancer”), which by your calibration requires h=3; ECHA documentation and Annex VI list this classification. Animal inhalation and developmental studies report reproductive/developmental effects (rats, rabbits) consistent with demonstrated developmental toxicity at high exposures, supporting a mechanistic concern (epoxide reactivity and metabolism of styrene to styrene oxide) rather than a purely theoretical mechanism. For typical topical cosmetic uses, systemic exposure from deliberate cosmetic formulation appears likely low but not zero (reactive epoxide, some dermal penetration is possible), so exposure scored as 1 (low but measurable). Sources: ECHA harmonised classification and registration dossier; NIOSH/CDC reproductive inhalation study. (See sources.)

ECHA regulatory hazard statements

  • H350

What to use instead

Pregnancy-safe ingredients that serve a similar function:

FAQ

styrene oxide est-il sûr pendant la grossesse ?
Styrene oxide (CAS 96-09-3) has a harmonised CLP classification in the EU including Carc. 1B (H350: “May cause cancer”), which by your calibration requires h=3; ECHA documentation and Annex VI list this classification. Animal inhalation and developmental studies report reproductive/developmental effects (rats, rabbits) consistent with demonstrated developmental toxicity at high exposures, supporting a mechanistic concern (epoxide reactivity and metabolism of styrene to styrene oxide) rather than a purely theoretical mechanism. For typical topical cosmetic uses, systemic exposure from deliberate cosmetic formulation appears likely low but not zero (reactive epoxide, some dermal penetration is possible), so exposure scored as 1 (low but measurable). Sources: ECHA harmonised classification and registration dossier; NIOSH/CDC reproductive inhalation study. (See sources.)
styrene oxide est-il sûr pendant l'allaitement ?
Same hazard basis applies for breastfeeding: harmonised H350 drives h=3. Mechanistic concerns (reactive epoxide, demonstrated adverse effects in animal reproductive/developmental studies) support m=2. Dermal/topical cosmetic exposure to nursing parent expected to be low but measurable (e=1); transfer in milk is plausible for small lipophilic molecules but specific human lactation transfer data for styrene oxide are lacking (see sources).
styrene oxide est-il sûr pour la peau de bébé ?
Hazard remains h=3 because of the harmonised carcinogen classification (H350). Mechanism rating m=2 reflects demonstrated animal reproductive/developmental toxicity and the reactive epoxide chemistry. Exposure for baby skin is increased by +1 vs adult because infant skin barrier immaturity and higher surface-area-to-weight ratio make dermal uptake more likely; therefore e=2 (moderate) if the ingredient were present on skin. Note: styrene oxide is not a normal cosmetic ingredient and is highly reactive; presence in finished cosmetic products would be unexpected and problematic. See ECHA harmonised classification and animal inhalation/developmental studies below.
Comment VeriMom évalue-t-il styrene oxide ?
VeriMom évalue styrene oxide à 20/100 (risque élevé) sur la base du statut EU CosIng, des classifications ECHA et des études PubMed.
Quelles sont les alternatives sûres à styrene oxide pendant la grossesse ?
Consultez notre liste d'alternatives sûres à styrene oxide basée sur une fonction similaire et une classification sans risques connus.

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Avis Médical

Ces informations sont fournies à titre éducatif uniquement et ne constituent pas un avis médical. Les scores de sécurité sont basés sur des données accessibles au public et peuvent ne pas refléter tous les risques. Consultez toujours votre professionnel de santé avant d'utiliser tout produit pendant la grossesse ou l'allaitement.

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