VeriMomDois-je éviter phenolphthalein pendant la grossesse ? | VeriMom
Phenolphthalein has harmonised CLP classifications for reproductive toxicity including H360 (per ECHA brief profile / Annex VI) and H361f (suspected of damaging fertility), which meets the criterion for H360-level evidence → h=3. There is experimental evidence of estrogenic activity/in vitro endocrine effects and genotoxicity in animal/in vitro studies supporting a demonstrated mechanism (m=2). For typical topical cosmetic use systemic absorption is likely low but measurable, so exposure is scored e=1. Sources: ECHA harmonised classification, NTP/animal carcinogenicity/genotoxicity literature, in vitro estrogenic reports.
ECHA regulatory hazard statements
- •H350
- •H361F
What to use instead
Pregnancy-safe ingredients that serve a similar function:
FAQ
- phenolphthalein est-il sûr pendant la grossesse ?
- Phenolphthalein has harmonised CLP classifications for reproductive toxicity including H360 (per ECHA brief profile / Annex VI) and H361f (suspected of damaging fertility), which meets the criterion for H360-level evidence → h=3. There is experimental evidence of estrogenic activity/in vitro endocrine effects and genotoxicity in animal/in vitro studies supporting a demonstrated mechanism (m=2). For typical topical cosmetic use systemic absorption is likely low but measurable, so exposure is scored e=1. Sources: ECHA harmonised classification, NTP/animal carcinogenicity/genotoxicity literature, in vitro estrogenic reports.
- phenolphthalein est-il sûr pendant l'allaitement ?
- Harmonised classification includes reproductive concerns (H361f) and the substance has animal/genotoxic and in vitro estrogenic data; breastfeeding is scored h=2 because harmonised H361 (suspected reproductive hazard) supports 'suspected' rather than confirmed systemic teratogen for lactation exposure. Mechanistic data (in vitro estrogenic activity, genotoxicity) give m=2. Systemic absorption from topical use is likely low but measurable, so milk transfer risk is low but not negligible (e=1).
- phenolphthalein est-il sûr pour la peau de bébé ?
- For infant topical exposure (0–3 yr) the hazard score is maintained at h=2 (suspected reproductive/toxic effects per harmonised H361; H360-level evidence applies to developmental systemic teratogenesis but infant-skin–specific teratogenic data are not available so h is not escalated to 3). No infant‑specific mechanistic data identified, so m=0 (do not increase m without infant-specific evidence). Adult topical absorption judged low but measurable (adult e=1), and per instruction baby skin exposure is increased by +1 → e=2. Overall infant dermal exposure could be higher due to immature barrier and higher surface-area-to-weight ratio. Sources cited below.
- Comment VeriMom évalue-t-il phenolphthalein ?
- VeriMom évalue phenolphthalein à 20/100 (risque élevé) sur la base du statut EU CosIng, des classifications ECHA et des études PubMed.
- Quelles sont les alternatives sûres à phenolphthalein pendant la grossesse ?
- Consultez notre liste d'alternatives sûres à phenolphthalein basée sur une fonction similaire et une classification sans risques connus.
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Avis Médical
Ces informations sont fournies à titre éducatif uniquement et ne constituent pas un avis médical. Les scores de sécurité sont basés sur des données accessibles au public et peuvent ne pas refléter tous les risques. Consultez toujours votre professionnel de santé avant d'utiliser tout produit pendant la grossesse ou l'allaitement.