VeriMomDois-je éviter nitrous oxide pendant la grossesse ? | VeriMom
Dinitrogen oxide (nitrous oxide, CAS 10024-97-2) now has a harmonised CLP classification in the EU as Repr. 1B (H360Df) (Official Journal / CLP Annex VI update), which by calibration requires h=3. The mechanistic literature shows demonstrated inactivation of methionine‑synthase / perturbation of folate‑B12 pathways in animals and human cells (PubMed), supporting m=2. For normal topical cosmetic use the expected topical dermal/systemic absorption from a finished cosmetic product is negligible, so exposure (e) for pregnancy from topical use is scored 0; however inhalation (medical or recreational) is a separate, high‑exposure route and is outside routine cosmetic topical exposure assumptions.
ECHA regulatory hazard statements
- •H360DF
What to use instead
Pregnancy-safe ingredients that serve a similar function:
FAQ
- nitrous oxide est-il sûr pendant la grossesse ?
- Dinitrogen oxide (nitrous oxide, CAS 10024-97-2) now has a harmonised CLP classification in the EU as Repr. 1B (H360Df) (Official Journal / CLP Annex VI update), which by calibration requires h=3. The mechanistic literature shows demonstrated inactivation of methionine‑synthase / perturbation of folate‑B12 pathways in animals and human cells (PubMed), supporting m=2. For normal topical cosmetic use the expected topical dermal/systemic absorption from a finished cosmetic product is negligible, so exposure (e) for pregnancy from topical use is scored 0; however inhalation (medical or recreational) is a separate, high‑exposure route and is outside routine cosmetic topical exposure assumptions.
- nitrous oxide est-il sûr pendant l'allaitement ?
- Harmonised Repr.1B (H360Df) applies to the substance (h=3). Mechanism is the same as for pregnancy (methionine synthase / folate interference documented) so m=2. For typical cosmetic topical application breastfeeding exposure is expected to be negligible (e=0). Inhalation/medical exposure would increase exposure but is not typical for cosmetics.
- nitrous oxide est-il sûr pour la peau de bébé ?
- Hazard remains h=3 because of the harmonised Repr.1B classification. Mechanistic evidence (B12/methionine synthase inhibition, folate perturbation) supports m=2. For infant skin (0–3 yr) assume increased potential exposure relative to adults; since the substance is not completely non‑absorbable and infants have a less mature barrier the exposure score is increased by +1 (adult e=0 → infant e=1). Topical cosmetic use still would normally produce negligible systemic uptake, but infant susceptibility and increased surface‑area‑to‑weight justify the +1 increase.
- Comment VeriMom évalue-t-il nitrous oxide ?
- VeriMom évalue nitrous oxide à 27/100 (risque élevé) sur la base du statut EU CosIng, des classifications ECHA et des études PubMed.
- Quelles sont les alternatives sûres à nitrous oxide pendant la grossesse ?
- Consultez notre liste d'alternatives sûres à nitrous oxide basée sur une fonction similaire et une classification sans risques connus.
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Avis Médical
Ces informations sont fournies à titre éducatif uniquement et ne constituent pas un avis médical. Les scores de sécurité sont basés sur des données accessibles au public et peuvent ne pas refléter tous les risques. Consultez toujours votre professionnel de santé avant d'utiliser tout produit pendant la grossesse ou l'allaitement.