VeriMomDois-je éviter methylene di-t-butylcresol pendant la grossesse ? | VeriMom
ECHA lists 6,6'-di-tert‑butyl‑2,2'‑methylenedi‑p‑cresol (CAS 119‑47‑1) with a harmonised classification for reproductive toxicity (Repr. 1B, H360F — “May damage fertility”), which by the scoring rules yields h=3. Animal reproductive/developmental findings are reported in regulatory dossiers (developmental NOAEL/LOAEL in non‑rodents in EPA/registration material), but a specific molecular reproductive mechanism is not established in the literature (m=1). For routine topical cosmetic use dermal absorption is likely low but not zero (lipophilic high‑molecular phenolic antioxidant), so exposure for a pregnant adult is scored as low but measurable (e=1). Sources: ECHA harmonised classification and registration/assessment data and regulatory toxicology summaries.
ECHA regulatory hazard statements
- •H360F
What to use instead
Pregnancy-safe ingredients that serve a similar function:
FAQ
- methylene di-t-butylcresol est-il sûr pendant la grossesse ?
- ECHA lists 6,6'-di-tert‑butyl‑2,2'‑methylenedi‑p‑cresol (CAS 119‑47‑1) with a harmonised classification for reproductive toxicity (Repr. 1B, H360F — “May damage fertility”), which by the scoring rules yields h=3. Animal reproductive/developmental findings are reported in regulatory dossiers (developmental NOAEL/LOAEL in non‑rodents in EPA/registration material), but a specific molecular reproductive mechanism is not established in the literature (m=1). For routine topical cosmetic use dermal absorption is likely low but not zero (lipophilic high‑molecular phenolic antioxidant), so exposure for a pregnant adult is scored as low but measurable (e=1). Sources: ECHA harmonised classification and registration/assessment data and regulatory toxicology summaries.
- methylene di-t-butylcresol est-il sûr pendant l'allaitement ?
- Same harmonised reproductive classification (Repr. 1B, H360F) applies and supports a high hazard score (h=3). No clear mechanistic data specific to lactational transfer was found (m=1). For topical cosmetic use, maternal dermal exposure is expected to be low but measurable; breastmilk transfer is plausible for lipophilic compounds but was not documented in available studies, so exposure is scored as low (e=1). Regulatory guidance therefore flags this substance for reproductive concern.
- methylene di-t-butylcresol est-il sûr pour la peau de bébé ?
- Hazard remains high because of the harmonised Repr.1B/H360F classification (h=3). No infant‑specific mechanism data was identified (m=1). Because infant skin (0–3 yr) has higher absorption per body weight and an immature barrier, exposure score is increased by +1 relative to adults (adult e=1 → baby e=2) where dermal absorption is measurable. No infant dermal studies were located to justify changing hazard or mechanism scores.
- Comment VeriMom évalue-t-il methylene di-t-butylcresol ?
- VeriMom évalue methylene di-t-butylcresol à 27/100 (risque élevé) sur la base du statut EU CosIng, des classifications ECHA et des études PubMed.
- Quelles sont les alternatives sûres à methylene di-t-butylcresol pendant la grossesse ?
- Consultez notre liste d'alternatives sûres à methylene di-t-butylcresol basée sur une fonction similaire et une classification sans risques connus.
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Avis Médical
Ces informations sont fournies à titre éducatif uniquement et ne constituent pas un avis médical. Les scores de sécurité sont basés sur des données accessibles au public et peuvent ne pas refléter tous les risques. Consultez toujours votre professionnel de santé avant d'utiliser tout produit pendant la grossesse ou l'allaitement.