VeriMomDois-je éviter hydroxyanasatil retinoate pendant la grossesse ? | VeriMom
No harmonised Annex VI CLP classification was found for CAS 127471-94-7, but the substance is a retinoic acid ester (structural class known to interact with retinoid receptors). Retinoids/retinoic acid are well‑characterised developmental toxicants via RAR/RXR-mediated mechanisms (SCCS and regulatory literature treat vitamin A / some retinoids as reproductive/developmental hazards). Because there is no harmonised H360 entry for this specific CAS and no published specific reproductive animal/human data located for 127471-94-7, hazard is scored as structural/class-based concern only (h=1) while mechanism is rated high (RAR agonism well characterized). Topical absorption from cosmetics is likely low but measurable, so exposure is scored as 1. (Sources: SCCS Vitamin A opinion; supplier/patent records identifying this compound as a retinoate.).
ECHA regulatory hazard statements
- •H360
What to use instead
Pregnancy-safe ingredients that serve a similar function:
FAQ
- hydroxyanasatil retinoate est-il sûr pendant la grossesse ?
- No harmonised Annex VI CLP classification was found for CAS 127471-94-7, but the substance is a retinoic acid ester (structural class known to interact with retinoid receptors). Retinoids/retinoic acid are well‑characterised developmental toxicants via RAR/RXR-mediated mechanisms (SCCS and regulatory literature treat vitamin A / some retinoids as reproductive/developmental hazards). Because there is no harmonised H360 entry for this specific CAS and no published specific reproductive animal/human data located for 127471-94-7, hazard is scored as structural/class-based concern only (h=1) while mechanism is rated high (RAR agonism well characterized). Topical absorption from cosmetics is likely low but measurable, so exposure is scored as 1. (Sources: SCCS Vitamin A opinion; supplier/patent records identifying this compound as a retinoate.).
- hydroxyanasatil retinoate est-il sûr pendant l'allaitement ?
- Same structural/class‑based concern applies for breastfeeding: no specific reproductive/lactation studies found for this CAS, but retinoids have a known RAR/RXR mechanism. Systemic exposure after topical use is expected to be low but potentially measurable; transfer into breast milk has not been reported for this specific substance. Therefore hazard = 1 (structural/class alert), mechanism = 3, exposure = 1 (low but measurable).
- hydroxyanasatil retinoate est-il sûr pour la peau de bébé ?
- Infant skin (0–3 yr) has higher surface‑area‑to‑weight and an immature barrier; for a retinoate with measurable absorption in adults we increase exposure by +1 for babies. There are no infant‑specific toxicity or dermal developmental studies for this CAS, so hazard remains a structural/class alert (h=1) and mechanism remains retinoid receptor activity (m=3). Exposure is scored moderate (e=2) for baby skin due to increased per‑kg uptake from topical application.
- Comment VeriMom évalue-t-il hydroxyanasatil retinoate ?
- VeriMom évalue hydroxyanasatil retinoate à 33/100 (risque élevé) sur la base du statut EU CosIng, des classifications ECHA et des études PubMed.
- Quelles sont les alternatives sûres à hydroxyanasatil retinoate pendant la grossesse ?
- Consultez notre liste d'alternatives sûres à hydroxyanasatil retinoate basée sur une fonction similaire et une classification sans risques connus.
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Avis Médical
Ces informations sont fournies à titre éducatif uniquement et ne constituent pas un avis médical. Les scores de sécurité sont basés sur des données accessibles au public et peuvent ne pas refléter tous les risques. Consultez toujours votre professionnel de santé avant d'utiliser tout produit pendant la grossesse ou l'allaitement.