VeriMomDois-je éviter estradiol pendant la grossesse ? | VeriMom
Estradiol (17β‑estradiol, CAS 50-28-2) carries harmonised reproductive hazard classification (H360—may damage fertility or the unborn child) in EU classification sources and product SDSs, and medicinal product labeling/clinical guidance list estradiol as contraindicated in pregnancy. Estrogens cross the placenta and maternal/experimental studies show excess maternal estradiol alters fetal development. Topical/transdermal estradiol formulations are known to give systemic exposure, so topical cosmetic application with appreciable systemic absorption would expose the fetus. (ECHA classification/SDS; DailyMed drug labeling; animal and human studies).
ECHA regulatory hazard statements
- •H360
- •H360FD
- •H361
- •H362
What to use instead
Pregnancy-safe ingredients that serve a similar function:
FAQ
- estradiol est-il sûr pendant la grossesse ?
- Estradiol (17β‑estradiol, CAS 50-28-2) carries harmonised reproductive hazard classification (H360—may damage fertility or the unborn child) in EU classification sources and product SDSs, and medicinal product labeling/clinical guidance list estradiol as contraindicated in pregnancy. Estrogens cross the placenta and maternal/experimental studies show excess maternal estradiol alters fetal development. Topical/transdermal estradiol formulations are known to give systemic exposure, so topical cosmetic application with appreciable systemic absorption would expose the fetus. (ECHA classification/SDS; DailyMed drug labeling; animal and human studies).
- estradiol est-il sûr pendant l'allaitement ?
- Harmonised/label information and safety data sheets include H362 (may cause harm to breast‑fed children) and list lactation effects; clinical drug labels state estrogens are present in human milk and may reduce milk production and are contraindicated or advised against during breastfeeding. Estradiol is systemically bioactive and transfers into milk; topical/transdermal absorption can produce systemic levels. (ECHA/SDS; DailyMed; pharmacology literature).
- estradiol est-il sûr pour la peau de bébé ?
- Hazard (H360/H362) is intrinsic to the parent hormone and applies to infants: estradiol is a potent estrogen with well‑characterized receptor activity and documented developmental effects in animal and human observational studies. Exposure via product applied to infant skin would be of high concern because estradiol is absorbable transdermally (used clinically as transdermal therapy) and infant skin has higher surface‑area‑to‑weight and immature barrier — exposure rating increased for infant skin. No infant‑safe cosmetic use is supported. (ECHA/SDS; clinical/transdermal product literature; peer‑reviewed studies on maternal estradiol effects).
- Comment VeriMom évalue-t-il estradiol ?
- VeriMom évalue estradiol à 0/100 (risque élevé) sur la base du statut EU CosIng, des classifications ECHA et des études PubMed.
- Quelles sont les alternatives sûres à estradiol pendant la grossesse ?
- Consultez notre liste d'alternatives sûres à estradiol basée sur une fonction similaire et une classification sans risques connus.
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Avis Médical
Ces informations sont fournies à titre éducatif uniquement et ne constituent pas un avis médical. Les scores de sécurité sont basés sur des données accessibles au public et peuvent ne pas refléter tous les risques. Consultez toujours votre professionnel de santé avant d'utiliser tout produit pendant la grossesse ou l'allaitement.