VeriMomDois-je éviter clotrimazole pendant la grossesse ? | VeriMom
Clotrimazole is listed with a harmonised CLP classification of H361 (suspected of damaging fertility or the unborn child) on ECHA, which supports a ‘suspected’ reproductive hazard (h=2). A recent peer‑reviewed rat study showed that systemic exposure to clotrimazole altered maternal and fetal steroid hormone profiles via CYP/steroidogenesis inhibition (demonstrated mechanism → m=2). For typical topical/vaginal cosmetic/OTC use systemic absorption is minimal but measurable, so exposure from topical cosmetic use is rated low (e=1). Sources: ECHA harmonised classification and PubMed study, plus product labeling on animal effects.
ECHA regulatory hazard statements
- •H361
What to use instead
Pregnancy-safe ingredients that serve a similar function:
FAQ
- clotrimazole est-il sûr pendant la grossesse ?
- Clotrimazole is listed with a harmonised CLP classification of H361 (suspected of damaging fertility or the unborn child) on ECHA, which supports a ‘suspected’ reproductive hazard (h=2). A recent peer‑reviewed rat study showed that systemic exposure to clotrimazole altered maternal and fetal steroid hormone profiles via CYP/steroidogenesis inhibition (demonstrated mechanism → m=2). For typical topical/vaginal cosmetic/OTC use systemic absorption is minimal but measurable, so exposure from topical cosmetic use is rated low (e=1). Sources: ECHA harmonised classification and PubMed study, plus product labeling on animal effects.
- clotrimazole est-il sûr pendant l'allaitement ?
- Harmonised H361 classification and animal data (CYP inhibition and steroid changes) provide evidence for a suspected reproductive/developmental hazard (h=2) and a demonstrated mechanistic effect (m=2). Topical use shows minimal but measurable systemic absorption and is therefore given low exposure (e=1); breastfeeding guidance notes limited systemic exposure with topical use but advises use only if benefits outweigh risks in some labels.
- clotrimazole est-il sûr pour la peau de bébé ?
- Hazard (h=2) remains based on harmonised H361 and animal evidence; mechanism (m=2) is the same (CYP/steroidogenesis effects demonstrated in animals). Exposure is increased by one band for infants because infant skin has higher absorption — adult topical e=1 → baby e=2 (measurable/moderate exposure potential for 0–3 yr). There is limited infant‑specific reproductive/toxicity data; topical clotrimazole has been used in infants in clinical studies but systemic safety data are limited.
- Comment VeriMom évalue-t-il clotrimazole ?
- VeriMom évalue clotrimazole à 20/100 (risque élevé) sur la base du statut EU CosIng, des classifications ECHA et des études PubMed.
- Quelles sont les alternatives sûres à clotrimazole pendant la grossesse ?
- Consultez notre liste d'alternatives sûres à clotrimazole basée sur une fonction similaire et une classification sans risques connus.
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Avis Médical
Ces informations sont fournies à titre éducatif uniquement et ne constituent pas un avis médical. Les scores de sécurité sont basés sur des données accessibles au public et peuvent ne pas refléter tous les risques. Consultez toujours votre professionnel de santé avant d'utiliser tout produit pendant la grossesse ou l'allaitement.