VeriMomDois-je éviter benzophenone-1 pendant la grossesse ? | VeriMom
Benzophenone-1 (2,4-dihydroxybenzophenone; CAS 131-56-6) has a harmonised ECHA classification for reproductive toxicity H361 (suspected of damaging fertility or the unborn child), which justifies h=2. Peer-reviewed in vitro and mechanistic studies show endocrine activity (estrogenic activity in MCF‑7 cells and inhibition of steroidogenic enzymes including 17β‑HSD3), supporting a demonstrated mechanism (m=2). As a small lipophilic UV‑filter with documented biological activity and use in topical products, dermal uptake is plausible and judged moderate for pregnancy exposure (e=2). Sources: ECHA C&L / substance profile; SCCS activity on BP‑1; PubMed mechanistic studies; CIR review.
ECHA regulatory hazard statements
- •H361
What to use instead
Pregnancy-safe ingredients that serve a similar function:
FAQ
- benzophenone-1 est-il sûr pendant la grossesse ?
- Benzophenone-1 (2,4-dihydroxybenzophenone; CAS 131-56-6) has a harmonised ECHA classification for reproductive toxicity H361 (suspected of damaging fertility or the unborn child), which justifies h=2. Peer-reviewed in vitro and mechanistic studies show endocrine activity (estrogenic activity in MCF‑7 cells and inhibition of steroidogenic enzymes including 17β‑HSD3), supporting a demonstrated mechanism (m=2). As a small lipophilic UV‑filter with documented biological activity and use in topical products, dermal uptake is plausible and judged moderate for pregnancy exposure (e=2). Sources: ECHA C&L / substance profile; SCCS activity on BP‑1; PubMed mechanistic studies; CIR review.
- benzophenone-1 est-il sûr pendant l'allaitement ?
- Same hazard basis (ECHA harmonised H361) applies for lactation (h=2). Mechanistic data (in vitro estrogenic effects and inhibition of steroidogenic enzymes) indicate potential endocrine activity relevant to breast tissue and hormonal regulation (m=2). Exposure via systemic uptake from topical use is assessed as moderate (e=2), consistent with other benzophenone UV‑filters which show measurable absorption and systemic detection in biomonitoring studies (see cited literature).
- benzophenone-1 est-il sûr pour la peau de bébé ?
- Hazard (h=2) and mechanistic (m=2) ratings follow the harmonised classification and the demonstrated endocrine activity. Exposure for infants (0–3 yr) is increased by one category compared with adults because immature/ thinner skin and higher surface‑area‑to‑weight ratio raise dermal uptake for ingredients with measurable absorption, so e=3. There is no infant‑specific evidence to increase h or m further.
- Comment VeriMom évalue-t-il benzophenone-1 ?
- VeriMom évalue benzophenone-1 à 13/100 (risque élevé) sur la base du statut EU CosIng, des classifications ECHA et des études PubMed.
- Quelles sont les alternatives sûres à benzophenone-1 pendant la grossesse ?
- Consultez notre liste d'alternatives sûres à benzophenone-1 basée sur une fonction similaire et une classification sans risques connus.
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Avis Médical
Ces informations sont fournies à titre éducatif uniquement et ne constituent pas un avis médical. Les scores de sécurité sont basés sur des données accessibles au public et peuvent ne pas refléter tous les risques. Consultez toujours votre professionnel de santé avant d'utiliser tout produit pendant la grossesse ou l'allaitement.