VeriMomDois-je éviter aziridine pendant la grossesse ? | VeriMom
Aziridine (ethyleneimine, CAS 151-56-4) has harmonised/regulatory classifications and authoritative toxicology indicating mutagenic and carcinogenic properties (ECHA registration/C&L info, EPA/IRIS, IARC). Harmonised flags for reproductive hazard (suspected; H361 reported in regulatory sources) support 'suspected' reproductive hazard (h=2). The mechanism is well-supported as an alkylating/genotoxic agent (demonstrated genotoxicity/mutagenicity) so m=2. For topical exposure, aziridine is a small, reactive molecule with reported dermal absorption and clear systemic toxicity in occupational/animal data, so exposure from topical use would be at least measurable/moderate (e=2). Sources: ECHA dossier/C&L summaries, EPA IRIS/FACT sheet, NIOSH/NIH toxicology summaries, IARC summary.
ECHA regulatory hazard statements
- •H350
What to use instead
Pregnancy-safe ingredients that serve a similar function:
FAQ
- aziridine est-il sûr pendant la grossesse ?
- Aziridine (ethyleneimine, CAS 151-56-4) has harmonised/regulatory classifications and authoritative toxicology indicating mutagenic and carcinogenic properties (ECHA registration/C&L info, EPA/IRIS, IARC). Harmonised flags for reproductive hazard (suspected; H361 reported in regulatory sources) support 'suspected' reproductive hazard (h=2). The mechanism is well-supported as an alkylating/genotoxic agent (demonstrated genotoxicity/mutagenicity) so m=2. For topical exposure, aziridine is a small, reactive molecule with reported dermal absorption and clear systemic toxicity in occupational/animal data, so exposure from topical use would be at least measurable/moderate (e=2). Sources: ECHA dossier/C&L summaries, EPA IRIS/FACT sheet, NIOSH/NIH toxicology summaries, IARC summary.
- aziridine est-il sûr pendant l'allaitement ?
- Same hazard and mechanism rationale as pregnancy (suspected reproductive/teratogenic risk via genotoxic/alkylating activity). No specific human lactation transfer data located, but systemic toxicity and dermal absorption reported in authoritative sources imply measurable maternal exposure and potential for transfer into breastmilk (therefore e=2).
- aziridine est-il sûr pour la peau de bébé ?
- Hazard and mechanism as above (h=2, m=2). Because infant skin (0–3 yr) has higher surface-area-to-weight and an immature barrier, exposure score increases by +1 relative to adult topical exposure (adult e=2 → baby e=3). There is no infant-specific toxicokinetic evidence to change hazard or mechanism scores, only exposure.
- Comment VeriMom évalue-t-il aziridine ?
- VeriMom évalue aziridine à 13/100 (risque élevé) sur la base du statut EU CosIng, des classifications ECHA et des études PubMed.
- Quelles sont les alternatives sûres à aziridine pendant la grossesse ?
- Consultez notre liste d'alternatives sûres à aziridine basée sur une fonction similaire et une classification sans risques connus.
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Avis Médical
Ces informations sont fournies à titre éducatif uniquement et ne constituent pas un avis médical. Les scores de sécurité sont basés sur des données accessibles au public et peuvent ne pas refléter tous les risques. Consultez toujours votre professionnel de santé avant d'utiliser tout produit pendant la grossesse ou l'allaitement.