VeriMomDois-je éviter 2,3-epoxypropyltrimoniium chloride pendant la grossesse ? | VeriMom
Harmonised EU CLP classifications list 2,3-epoxypropyltrimethylammonium chloride (glycidyl trimethylammonium chloride, CAS 3033-77-0) with carcinogenic/mutagenic/reprotoxic categories including H350 and H361F (suspected adverse effects on fertility); this legally binding harmonised classification justifies a 'suspected' reproductive hazard (h=2). ECHA/CLP listings and registration dossier indicate mutagenic/carcinogenic/reprotoxic concerns, and animal/experimental literature on quaternary ammonium compounds shows reproductive/endocrine effects supporting a demonstrated mechanism (m=2). For typical topical cosmetic uses absorption is likely low but potentially measurable for a small reactive glycidyl/quaternary ammonium molecule, so exposure for a pregnant adult is scored as low-measurable (e=1).
ECHA regulatory hazard statements
- •H350
- •H361F
What to use instead
Pregnancy-safe ingredients that serve a similar function:
FAQ
- 2,3-epoxypropyltrimoniium chloride est-il sûr pendant la grossesse ?
- Harmonised EU CLP classifications list 2,3-epoxypropyltrimethylammonium chloride (glycidyl trimethylammonium chloride, CAS 3033-77-0) with carcinogenic/mutagenic/reprotoxic categories including H350 and H361F (suspected adverse effects on fertility); this legally binding harmonised classification justifies a 'suspected' reproductive hazard (h=2). ECHA/CLP listings and registration dossier indicate mutagenic/carcinogenic/reprotoxic concerns, and animal/experimental literature on quaternary ammonium compounds shows reproductive/endocrine effects supporting a demonstrated mechanism (m=2). For typical topical cosmetic uses absorption is likely low but potentially measurable for a small reactive glycidyl/quaternary ammonium molecule, so exposure for a pregnant adult is scored as low-measurable (e=1).
- 2,3-epoxypropyltrimoniium chloride est-il sûr pendant l'allaitement ?
- Because the substance carries harmonised H-codes including suspected reproductive toxicity (H361F) and has mechanistic/animal evidence of reproductive/endocrine disruption, it is scored as 'suspected' for breast-feeding (h=2) with demonstrated mechanism evidence from QAC literature (m=2). There are no direct, high-quality human lactation-transfer studies found; expected dermal exposure from cosmetics would be low but measurable (e=1).
- 2,3-epoxypropyltrimoniium chloride est-il sûr pour la peau de bébé ?
- Hazard remains 'suspected' (h=2) due to the legally harmonised classifications and supporting toxicology; mechanism evidence from quaternary ammonium/glycidyl reactivity supports m=2. Infant skin has higher absorption (immature barrier, higher surface-area-to-weight), so exposure score is increased by +1 versus adult topical use (adult e=1 → baby e=2) even though infant-specific absorption data for this chemical were not found.
- Comment VeriMom évalue-t-il 2,3-epoxypropyltrimoniium chloride ?
- VeriMom évalue 2,3-epoxypropyltrimoniium chloride à 20/100 (risque élevé) sur la base du statut EU CosIng, des classifications ECHA et des études PubMed.
- Quelles sont les alternatives sûres à 2,3-epoxypropyltrimoniium chloride pendant la grossesse ?
- Consultez notre liste d'alternatives sûres à 2,3-epoxypropyltrimoniium chloride basée sur une fonction similaire et une classification sans risques connus.
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Avis Médical
Ces informations sont fournies à titre éducatif uniquement et ne constituent pas un avis médical. Les scores de sécurité sont basés sur des données accessibles au public et peuvent ne pas refléter tous les risques. Consultez toujours votre professionnel de santé avant d'utiliser tout produit pendant la grossesse ou l'allaitement.