¿Es glycyrrhiza uralensis root extract seguro durante el embarazo?
No harmonised CLP reproductive classification (ECHA Annex VI) or SCCS/CIR conclusion that this extract is a reproductive teratogen; therefore hazard score remains 0 per rules. However, multiple peer-reviewed reports show constituent-specific endocrine activity in vitro (e.g., liquiritigenin is an ER agonist; glycyrrhizin/glycyrrhetinic acid have biological activity), so a demonstrated mechanistic effect is present (m=2). For topical use, systemic exposure is low but measurable depending on formulation, so exposure scored as 1. Sources: ECHA (no harmonised classification), PubMed (in vitro endocrine activity of licorice constituents), PubChem (constituent data), CosIng/EWG summaries.
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Frequently asked questions
- ¿Es glycyrrhiza uralensis root extract seguro durante el embarazo?
- No harmonised CLP reproductive classification (ECHA Annex VI) or SCCS/CIR conclusion that this extract is a reproductive teratogen; therefore hazard score remains 0 per rules. However, multiple peer-reviewed reports show constituent-specific endocrine activity in vitro (e.g., liquiritigenin is an ER agonist; glycyrrhizin/glycyrrhetinic acid have biological activity), so a demonstrated mechanistic effect is present (m=2). For topical use, systemic exposure is low but measurable depending on formulation, so exposure scored as 1. Sources: ECHA (no harmonised classification), PubMed (in vitro endocrine activity of licorice constituents), PubChem (constituent data), CosIng/EWG summaries.
- ¿Es glycyrrhiza uralensis root extract seguro durante la lactancia?
- No human/animal data establishing reproductive or developmental toxicity via dermal cosmetic use or lactation and no harmonised classification; hazard remains 0. Mechanistic in vitro endocrine activity of constituents supports m=2. Dermal absorption from cosmetics is low but measurable; breastmilk transfer after topical cosmetic use is unlikely but not well studied, so exposure scored 1. Sources: PubMed (constituent endocrine activity), ECHA (no CLP reprotox classification), PubChem, EWG.
- ¿Es glycyrrhiza uralensis root extract seguro para la piel del bebé?
- No infant-specific evidence of reproductive/developmental toxicity from cosmetic topical use and no harmonised reprotoxic classification; hazard remains 0. Mechanistic evidence (in vitro estrogenic activity of constituents) justifies m=2. Exposure is increased for babies vs adults due to immature barrier and higher surface-area-to-weight; adult exposure scored 1 -> baby exposure increased to 2. Sources: PubMed (mechanistic studies on liquiritigenin/glycyrrhizin), CosIng/PubChem summaries, EWG.
- ¿Cómo puntúa VeriMom a glycyrrhiza uralensis root extract?
- VeriMom puntúa glycyrrhiza uralensis root extract en 80/100 (riesgo bajo) según el estado EU CosIng, clasificaciones ECHA y estudios PubMed.
- ¿Cuáles son las alternativas seguras a glycyrrhiza uralensis root extract en el embarazo?
- Consulta nuestra lista de alternativas seguras a glycyrrhiza uralensis root extract según función similar y clasificación sin riesgos conocidos.
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Aviso Médico
Esta información es solo para fines educativos y no constituye asesoramiento médico. Las puntuaciones de seguridad se basan en datos disponibles públicamente y pueden no reflejar todos los riesgos. Siempre consulte a su profesional de salud antes de usar cualquier producto durante el embarazo o la lactancia.