VeriMom¿Debo evitar trimethyl pentanyl diisobutyrate durante el embarazo? | VeriMom
Trimethyl pentanyl diisobutyrate (TXIB; CAS 6846-50-0) has a harmonised/suspected reproductive hazard classification (H361) in regulatory sources and registration dossiers reporting reduced implant numbers and reduced litter weights in an OECD 421 rat study, supporting a suspected reproductive hazard. (ECHA registration dossier and SDS reporting H361; see sources). In vitro and ex vivo studies (fetal testis organ culture; gonadal cell lines) show biologically plausible effects on reproductive endpoints/sex-hormone related parameters, indicating a demonstrated mechanistic signal. Topical cosmetic exposure would generally give low but measurable systemic exposure (so e=1) for pregnant adults absent product-specific dermal absorption data.
ECHA regulatory hazard statements
- •H361
What to use instead
Pregnancy-safe ingredients that serve a similar function:
FAQ
- ¿Es trimethyl pentanyl diisobutyrate seguro durante el embarazo?
- Trimethyl pentanyl diisobutyrate (TXIB; CAS 6846-50-0) has a harmonised/suspected reproductive hazard classification (H361) in regulatory sources and registration dossiers reporting reduced implant numbers and reduced litter weights in an OECD 421 rat study, supporting a suspected reproductive hazard. (ECHA registration dossier and SDS reporting H361; see sources). In vitro and ex vivo studies (fetal testis organ culture; gonadal cell lines) show biologically plausible effects on reproductive endpoints/sex-hormone related parameters, indicating a demonstrated mechanistic signal. Topical cosmetic exposure would generally give low but measurable systemic exposure (so e=1) for pregnant adults absent product-specific dermal absorption data.
- ¿Es trimethyl pentanyl diisobutyrate seguro durante la lactancia?
- Same hazard basis applies (harmonised H361 / OECD 421 reproductive findings). Mechanistic data (in vitro/ex vivo endocrine-related effects and interactions with sex-hormone binding protein) support potential for reproductive/endocrine activity. With typical topical cosmetic use, maternal systemic exposure is expected to be low but measurable; specific data on transfer into human milk are not available, so exposure is scored as low (e=1).
- ¿Es trimethyl pentanyl diisobutyrate seguro para la piel del bebé?
- Hazard and mechanistic evidence remain the same (H361; animal reproductive/developmental signals; in vitro/ex vivo endocrine-related findings). Infant skin has higher absorption per kg, so exposure score is increased by +1 versus adults (adult e=1 → baby e=2) in the absence of definitive dermal absorption data for cosmetic formulations intended for infants.
- ¿Cómo puntúa VeriMom a trimethyl pentanyl diisobutyrate?
- VeriMom puntúa trimethyl pentanyl diisobutyrate en 20/100 (riesgo alto) según el estado EU CosIng, clasificaciones ECHA y estudios PubMed.
- ¿Cuáles son las alternativas seguras a trimethyl pentanyl diisobutyrate en el embarazo?
- Consulta nuestra lista de alternativas seguras a trimethyl pentanyl diisobutyrate según función similar y clasificación sin riesgos conocidos.
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Aviso Médico
Esta información es solo para fines educativos y no constituye asesoramiento médico. Las puntuaciones de seguridad se basan en datos disponibles públicamente y pueden no reflejar todos los riesgos. Siempre consulte a su profesional de salud antes de usar cualquier producto durante el embarazo o la lactancia.