VeriMom¿Debo evitar theophylline durante el embarazo? | VeriMom
Animal studies (mouse continuous-breeding, NTP/NIEHS; and rabbit developmental studies) report reduced pup numbers, fetal effects and teratogenicity at high systemic doses, supporting a suspected reproductive/developmental hazard. Theophylline crosses the placenta in humans/animals (demonstrated placental transfer). For topical cosmetic use maternal systemic exposure is likely low but measurable, so exposure to the fetus from maternal use is possible but expected to be limited. (Sources: NTP reproductive study; rabbit teratogenicity study; pharmacokinetic/label notes on placental transfer).
ECHA regulatory hazard statements
- •H360D
What to use instead
Pregnancy-safe ingredients that serve a similar function:
FAQ
- ¿Es theophylline seguro durante el embarazo?
- Animal studies (mouse continuous-breeding, NTP/NIEHS; and rabbit developmental studies) report reduced pup numbers, fetal effects and teratogenicity at high systemic doses, supporting a suspected reproductive/developmental hazard. Theophylline crosses the placenta in humans/animals (demonstrated placental transfer). For topical cosmetic use maternal systemic exposure is likely low but measurable, so exposure to the fetus from maternal use is possible but expected to be limited. (Sources: NTP reproductive study; rabbit teratogenicity study; pharmacokinetic/label notes on placental transfer).
- ¿Es theophylline seguro durante la lactancia?
- Theophylline is known to be excreted into human breast milk and neonatal effects have been reported following maternal administration; animal reproductive/developmental evidence also exists. Mechanistic evidence includes demonstrated transfer into milk. For topical cosmetic use maternal systemic uptake is likely low but measurable so infant exposure via milk is possible but expected to be limited for cosmetic use.
- ¿Es theophylline seguro para la piel del bebé?
- Animal data indicate reproductive/developmental toxicity at systemic doses; theophylline also crosses biological barriers (placenta, milk) indicating demonstrated distribution. Infant skin (0–3 yr) has higher dermal uptake per surface-area-to-weight; therefore exposure (e) is increased by +1 versus adults when the ingredient has measurable absorption. There is no infant-specific data showing a different hazard classification, but systemic developmental/neurologic concerns from theophylline support a suspected hazard for infants if systemic exposure occurs.
- ¿Cómo puntúa VeriMom a theophylline?
- VeriMom puntúa theophylline en 20/100 (riesgo alto) según el estado EU CosIng, clasificaciones ECHA y estudios PubMed.
- ¿Cuáles son las alternativas seguras a theophylline en el embarazo?
- Consulta nuestra lista de alternativas seguras a theophylline según función similar y clasificación sin riesgos conocidos.
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Aviso Médico
Esta información es solo para fines educativos y no constituye asesoramiento médico. Las puntuaciones de seguridad se basan en datos disponibles públicamente y pueden no reflejar todos los riesgos. Siempre consulte a su profesional de salud antes de usar cualquier producto durante el embarazo o la lactancia.