VeriMom¿Debo evitar plectranthus barbatus root extract durante el embarazo? | VeriMom
No EU cosmetic ban/restriction was found for Plectranthus/Coleus (INCI listed in the EU Official Journal), but the root extract contains forskolin. Forskolin has been shown to induce endocrine disturbances in human placental JEG‑3 cells (in vitro) and an older rat study reported anti‑implantation/delayed fetal effects — therefore reproductive hazard is “suspected” (h=2) with a demonstrated mechanism (m=2). An in vitro skin diffusion study showed forskolin can permeate human skin and permeation is enhanced when delivered in the crude P. barbatus root extract, so topical exposure is measurable/moderate (e=2). Sources: EU CosIng/Official Journal; in vitro placental study (PMCID: PMC9317975); in vitro skin diffusion J Nat Prod (Chen et al.).
What to use instead
Pregnancy-safe ingredients that serve a similar function:
FAQ
- ¿Es plectranthus barbatus root extract seguro durante el embarazo?
- No EU cosmetic ban/restriction was found for Plectranthus/Coleus (INCI listed in the EU Official Journal), but the root extract contains forskolin. Forskolin has been shown to induce endocrine disturbances in human placental JEG‑3 cells (in vitro) and an older rat study reported anti‑implantation/delayed fetal effects — therefore reproductive hazard is “suspected” (h=2) with a demonstrated mechanism (m=2). An in vitro skin diffusion study showed forskolin can permeate human skin and permeation is enhanced when delivered in the crude P. barbatus root extract, so topical exposure is measurable/moderate (e=2). Sources: EU CosIng/Official Journal; in vitro placental study (PMCID: PMC9317975); in vitro skin diffusion J Nat Prod (Chen et al.).
- ¿Es plectranthus barbatus root extract seguro durante la lactancia?
- There are no reliable human milk/excretion studies for Plectranthus/forskolin; guidance resources warn against oral use in pregnancy/lactation due to limited safety data. Because systemic exposure to forskolin could theoretically affect nursing infants but direct evidence for adverse effects via breastmilk is lacking, assign a low/class‑based concern (h=1) with a theoretical mechanism (m=1). Topical cosmetic use has low but measurable systemic absorption potential (e=1). Sources: LactMed/NCBI Monograph; WebMD summary; PMC placental study (mechanistic relevance).
- ¿Es plectranthus barbatus root extract seguro para la piel del bebé?
- No infant‑specific adverse dermatologic or developmental data were found for topical Plectranthus barbatus root extract. Per instructions, baby hazard (h) and mechanism (m) were not increased in the absence of infant‑specific evidence. However, because the extract (and forskolin within it) shows measurable skin permeation in vitro and infant skin has higher surface‑area‑to‑weight and immature barrier, exposure is increased for babies (+1 vs adult), giving e=3. Sources: J Nat Prod skin diffusion study; no baby‑specific safety studies located.
- ¿Cómo puntúa VeriMom a plectranthus barbatus root extract?
- VeriMom puntúa plectranthus barbatus root extract en 33/100 (riesgo alto) según el estado EU CosIng, clasificaciones ECHA y estudios PubMed.
- ¿Cuáles son las alternativas seguras a plectranthus barbatus root extract en el embarazo?
- Consulta nuestra lista de alternativas seguras a plectranthus barbatus root extract según función similar y clasificación sin riesgos conocidos.
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Aviso Médico
Esta información es solo para fines educativos y no constituye asesoramiento médico. Las puntuaciones de seguridad se basan en datos disponibles públicamente y pueden no reflejar todos los riesgos. Siempre consulte a su profesional de salud antes de usar cualquier producto durante el embarazo o la lactancia.