VeriMom¿Debo evitar nifedipine durante el embarazo? | VeriMom
Nifedipine is a systemic pharmaceutical (a dihydropyridine Ca2+ channel blocker) with evidence of fetal exposure: PBPK and clinical studies report substantial transplacental transfer (cord:maternal ratios ≈ ~1 in modelling and clinical measurements), and supplier safety data sheets list reproductive toxicity H361 (suspected of damaging fertility or the unborn child). Because ECHA-harmonised H360 classification was not identified but H361 is reported in SDS/registrations, hazard is scored as 'suspected' (h=2); mechanism is 'demonstrated' (m=2) because placental transfer and pharmacodynamic effects on uteroplacental blood flow are reported; topical cosmetic exposure is likely low but systemic if used as a drug, so for cosmetic topical use exposure is low (e=1). (Sources: PBPK and placental studies, systematic reviews and SDSs.).
ECHA regulatory hazard statements
- •H361
What to use instead
Pregnancy-safe ingredients that serve a similar function:
FAQ
- ¿Es nifedipine seguro durante el embarazo?
- Nifedipine is a systemic pharmaceutical (a dihydropyridine Ca2+ channel blocker) with evidence of fetal exposure: PBPK and clinical studies report substantial transplacental transfer (cord:maternal ratios ≈ ~1 in modelling and clinical measurements), and supplier safety data sheets list reproductive toxicity H361 (suspected of damaging fertility or the unborn child). Because ECHA-harmonised H360 classification was not identified but H361 is reported in SDS/registrations, hazard is scored as 'suspected' (h=2); mechanism is 'demonstrated' (m=2) because placental transfer and pharmacodynamic effects on uteroplacental blood flow are reported; topical cosmetic exposure is likely low but systemic if used as a drug, so for cosmetic topical use exposure is low (e=1). (Sources: PBPK and placental studies, systematic reviews and SDSs.).
- ¿Es nifedipine seguro durante la lactancia?
- Nifedipine is excreted into breastmilk in measurable but generally small amounts and is commonly considered compatible with breastfeeding in clinical guidance; supplier SDSs list reproductive toxicity H361 which supports a suspected reproductive hazard (h=2). Mechanistically, milk transfer is documented (so m=1–2), but adverse effects in infants are not robustly reported in the clinical literature; for topical cosmetic use exposure is expected to be low (e=1).
- ¿Es nifedipine seguro para la piel del bebé?
- There is no infant-specific dermal hazard data for 0–3 yr; nifedipine is systemically active and can cross placenta / enter milk, so parental systemic concern remains (h=2). For baby skin, because infants have higher skin absorption and the parent compound is moderately lipophilic (not completely non-absorbable), increase exposure score by +1 relative to adult topical use (adult e=1 → infant e=2). No direct evidence supports increasing hazard or mechanism beyond adult data in absence of infant-specific studies.
- ¿Cómo puntúa VeriMom a nifedipine?
- VeriMom puntúa nifedipine en 20/100 (riesgo alto) según el estado EU CosIng, clasificaciones ECHA y estudios PubMed.
- ¿Cuáles son las alternativas seguras a nifedipine en el embarazo?
- Consulta nuestra lista de alternativas seguras a nifedipine según función similar y clasificación sin riesgos conocidos.
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Aviso Médico
Esta información es solo para fines educativos y no constituye asesoramiento médico. Las puntuaciones de seguridad se basan en datos disponibles públicamente y pueden no reflejar todos los riesgos. Siempre consulte a su profesional de salud antes de usar cualquier producto durante el embarazo o la lactancia.