¿Debo evitar methotrexate durante el embarazo? | VeriMom

What to use instead

Pregnancy-safe ingredients that serve a similar function:

FAQ

¿Es methotrexate seguro durante el embarazo?

Methotrexate is a well‑known human teratogen and is contraindicated in pregnancy (FDA labeling: Pregnancy Category X) and causes fetal harm via folate antagonism (dihydrofolate reductase inhibition) with documented fetal malformations and pregnancy loss; this is a harmonised/high‑level reproductive hazard. Topical cosmetic use would give negligible systemic exposure in routine cosmetic scenarios, so exposure from cosmetic use is expected to be negligible. (Sources: FDA label; peer‑reviewed teratology literature; regulatory listings).

¿Es methotrexate seguro durante la lactancia?

Methotrexate is contraindicated in nursing mothers in drug labeling because of potential for serious adverse effects in the breastfed infant and its systemic distribution; mechanism (DHFR inhibition/antifolate) is established. For a cosmetic topical use scenario, maternal systemic exposure from a cosmetic product would be negligible, so milk transfer from cosmetic use is not expected.

¿Es methotrexate seguro para la piel del bebé?

Hazard is high (harmonised/regulatory teratogen/antimetabolite). For direct application to baby (0–3 yr) the immature barrier raises exposure compared with adults: even if adult topical absorption is negligible for a highly polar drug, the guidance requires raising the exposure score by +1 for baby skin when measurable absorption is possible. Therefore exposure = 1 for baby skin; mechanism (antifolate/DHFR inhibition) is well characterized.

¿Cómo puntúa VeriMom a methotrexate?

VeriMom puntúa methotrexate en 20/100 (riesgo alto) según el estado EU CosIng, clasificaciones ECHA y estudios PubMed.

¿Cuáles son las alternativas seguras a methotrexate en el embarazo?

Consulta nuestra lista de alternativas seguras a methotrexate según función similar y clasificación sin riesgos conocidos.