VeriMomHIGH RISK
¿Debo evitar methotrexate durante el embarazo? | VeriMom
Reviewed by VeriMom Editorial Team · Last reviewed
ECHA regulatory hazard statements
- •H360
What to use instead
Pregnancy-safe ingredients that serve a similar function:
Pregnancy-safe products to use instead
Products built around the safer ingredients above, scored "no known risks" or "low risk".
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Sources & references
Authoritative references used to score this ingredient.
Alternativas seguras a methotrexate en el embarazo | VeriMom
Ingredientes — Ingredientes
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FAQ
- ¿Es methotrexate seguro durante el embarazo?
- Methotrexate is a well‑known human teratogen and is contraindicated in pregnancy (FDA labeling: Pregnancy Category X) and causes fetal harm via folate antagonism (dihydrofolate reductase inhibition) with documented fetal malformations and pregnancy loss; this is a harmonised/high‑level reproductive hazard. Topical cosmetic use would give negligible systemic exposure in routine cosmetic scenarios, so exposure from cosmetic use is expected to be negligible. (Sources: FDA label; peer‑reviewed teratology literature; regulatory listings).
- ¿Es methotrexate seguro durante la lactancia?
- Methotrexate is contraindicated in nursing mothers in drug labeling because of potential for serious adverse effects in the breastfed infant and its systemic distribution; mechanism (DHFR inhibition/antifolate) is established. For a cosmetic topical use scenario, maternal systemic exposure from a cosmetic product would be negligible, so milk transfer from cosmetic use is not expected.
- ¿Es methotrexate seguro para la piel del bebé?
- Hazard is high (harmonised/regulatory teratogen/antimetabolite). For direct application to baby (0–3 yr) the immature barrier raises exposure compared with adults: even if adult topical absorption is negligible for a highly polar drug, the guidance requires raising the exposure score by +1 for baby skin when measurable absorption is possible. Therefore exposure = 1 for baby skin; mechanism (antifolate/DHFR inhibition) is well characterized.
- ¿Cómo puntúa VeriMom a methotrexate?
- VeriMom puntúa methotrexate en 20/100 (riesgo alto) según el estado EU CosIng, clasificaciones ECHA y estudios PubMed.
- ¿Cuáles son las alternativas seguras a methotrexate en el embarazo?
- Consulta nuestra lista de alternativas seguras a methotrexate según función similar y clasificación sin riesgos conocidos.
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Aviso Médico
Esta información es solo para fines educativos y no constituye asesoramiento médico. Las puntuaciones de seguridad se basan en datos disponibles públicamente y pueden no reflejar todos los riesgos. Siempre consulte a su profesional de salud antes de usar cualquier producto durante el embarazo o la lactancia.