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HIGH RISK

Should I Avoid tetrahydrofurfuryl methacrylate During Pregnancy? | VeriMom

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ECHA regulatory hazard statements

  • H360DF

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Authoritative references used to score this ingredient.

Pregnancy-Safe Alternatives to tetrahydrofurfuryl methacrylate | VeriMom

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FAQ

Is tetrahydrofurfuryl methacrylate safe during pregnancy?
Tetrahydrofurfuryl methacrylate (CAS 2455-24-5) has a harmonised CLP classification Repr. 1A H360Df (may damage fertility and the unborn child), which is legally binding in the EU and places it in CMR Category 1A; by calibration H360 => h=3. No well-characterized molecular mechanism for reproductive toxicity was found in public dossiers or the literature, so mechanism is scored as theoretical/unknown (m=1). For topical cosmetic exposure, dermal absorption is plausible (log Pow ≈1.8 and it's a low-molecular weight methacrylate) but not extremely high, so exposure is scored as low but measurable (e=1). Sources: EU delegated regulation / harmonised CLP listing and ECHA materials.
Is tetrahydrofurfuryl methacrylate safe while breastfeeding?
Harmonised classification H360Df (Repr. 1A) applies to reproductive/developmental hazards; per your scoring rules H360 => h=3 for breastfeeding context as well. Mechanistic data for transfer into human milk or a distinct lactation-specific mechanism were not identified (m=1). Dermal exposure during lactation is possible and considered low but measurable (e=1).
Is tetrahydrofurfuryl methacrylate safe for baby skin?
Because the substance carries harmonised H360Df (CMR Cat 1A) the hazard score for infant skin is h=3 (harmonised CMR overrides). No infant-specific mechanistic data were located (m=1). Exposure for babies (0–3 yr) is increased relative to adults due to immature skin barrier and higher surface-area-to-weight; adult exposure was scored e=1 so infant exposure is increased by +1 → e=2. No infant-specific absorption or toxicokinetic studies were found that would change hazard or mechanism scores.
How does VeriMom score tetrahydrofurfuryl methacrylate?
VeriMom scores tetrahydrofurfuryl methacrylate at 27/100 (high risk) based on EU CosIng status, ECHA hazard classifications, and peer-reviewed PubMed studies. Our scoring pipeline is fully transparent.
What are pregnancy-safe alternatives to tetrahydrofurfuryl methacrylate?
See our curated list of pregnancy-safe alternatives to tetrahydrofurfuryl methacrylate based on similar function and a no-known-risks safety band.

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Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice. Safety scores are based on publicly available data and may not reflect all risks. Always consult your healthcare provider before using any product during pregnancy or breastfeeding.

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