VeriMomDois-je éviter methotrexate pendant la grossesse ? | VeriMom
Methotrexate is a well‑known human teratogen and is contraindicated in pregnancy (FDA labeling: Pregnancy Category X) and causes fetal harm via folate antagonism (dihydrofolate reductase inhibition) with documented fetal malformations and pregnancy loss; this is a harmonised/high‑level reproductive hazard. Topical cosmetic use would give negligible systemic exposure in routine cosmetic scenarios, so exposure from cosmetic use is expected to be negligible. (Sources: FDA label; peer‑reviewed teratology literature; regulatory listings).
ECHA regulatory hazard statements
- •H360
What to use instead
Pregnancy-safe ingredients that serve a similar function:
FAQ
- methotrexate est-il sûr pendant la grossesse ?
- Methotrexate is a well‑known human teratogen and is contraindicated in pregnancy (FDA labeling: Pregnancy Category X) and causes fetal harm via folate antagonism (dihydrofolate reductase inhibition) with documented fetal malformations and pregnancy loss; this is a harmonised/high‑level reproductive hazard. Topical cosmetic use would give negligible systemic exposure in routine cosmetic scenarios, so exposure from cosmetic use is expected to be negligible. (Sources: FDA label; peer‑reviewed teratology literature; regulatory listings).
- methotrexate est-il sûr pendant l'allaitement ?
- Methotrexate is contraindicated in nursing mothers in drug labeling because of potential for serious adverse effects in the breastfed infant and its systemic distribution; mechanism (DHFR inhibition/antifolate) is established. For a cosmetic topical use scenario, maternal systemic exposure from a cosmetic product would be negligible, so milk transfer from cosmetic use is not expected.
- methotrexate est-il sûr pour la peau de bébé ?
- Hazard is high (harmonised/regulatory teratogen/antimetabolite). For direct application to baby (0–3 yr) the immature barrier raises exposure compared with adults: even if adult topical absorption is negligible for a highly polar drug, the guidance requires raising the exposure score by +1 for baby skin when measurable absorption is possible. Therefore exposure = 1 for baby skin; mechanism (antifolate/DHFR inhibition) is well characterized.
- Comment VeriMom évalue-t-il methotrexate ?
- VeriMom évalue methotrexate à 20/100 (risque élevé) sur la base du statut EU CosIng, des classifications ECHA et des études PubMed.
- Quelles sont les alternatives sûres à methotrexate pendant la grossesse ?
- Consultez notre liste d'alternatives sûres à methotrexate basée sur une fonction similaire et une classification sans risques connus.
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Avis Médical
Ces informations sont fournies à titre éducatif uniquement et ne constituent pas un avis médical. Les scores de sécurité sont basés sur des données accessibles au public et peuvent ne pas refléter tous les risques. Consultez toujours votre professionnel de santé avant d'utiliser tout produit pendant la grossesse ou l'allaitement.