trichosanthes kirilowii root extract hamilelikte güvenli mi?

Hamilelikte trichosanthes kirilowii root extract yerine kullanılabilecek güvenli alternatifler | VeriMom

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trichosanthes kirilowii root extract hamilelikte güvenli mi?

Animal and mechanistic data show trichosanthin (from T. kirilowii root) is embryotoxic/abortifacient and has been used clinically to induce abortion, so reproductive hazard is supported (h=2). The mechanism is demonstrated (ribosome‑inactivating protein with demonstrated abortion mechanisms in experimental studies), so m=2. For topical cosmetic use exposure is likely low but measurable (e=1) because extracts are applied topically and some dermal uptake or local activity is possible depending on formulation; however systemic exposure from typical cosmetic topical use is likely limited. ([pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/8102209/?utm_source=openai))

trichosanthes kirilowii root extract emzirirken güvenli mi?

Because the same demonstrable reproductive/embryotoxic hazard exists for trichosanthin and systemic exposure (even small) could theoretically transfer into breastmilk, breastfeeding is flagged at the same hazard and mechanism level (h=2, m=2). Expected dermal/topical exposure is low but measurable (e=1); no direct data on lactational transfer from topical cosmetic use were found. ([pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/8102209/?utm_source=openai))

trichosanthes kirilowii root extract bebek cildi için güvenli mi?

Hazard and mechanism are unchanged for infant skin (h=2, m=2) because the same toxic constituent (trichosanthin) is responsible. Exposure score is increased by +1 for baby skin to e=2 because infant skin has a higher surface‑area‑to‑weight ratio and less mature barrier, making dermal absorption and systemic exposure more likely from topical application of products containing the extract. No infant‑specific safety studies for topical T. kirilowii root extract were located. ([pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/8102209/?utm_source=openai))

VeriMom trichosanthes kirilowii root extract nasıl puanlıyor?

VeriMom trichosanthes kirilowii root extract'yi EU CosIng, ECHA sınıflandırmaları ve PubMed çalışmalarına göre 40/100 (orta risk) olarak puanlar.

Hamilelikte trichosanthes kirilowii root extract yerine neler kullanılabilir?

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