VeriMomdisodium glycyrrhizate hamilelikte güvenli mi?
No EU Annex II/III restriction or harmonised CLP classification for disodium glycyrrhizate was found, and CIR’s Final Report assessed disodium glycyrrhizate among licorice‑derived ingredients used in cosmetics and concluded safety in cosmetic use conditions. However, glycyrrhizic acid (parent molecule) has a demonstrated mechanism — inhibition of 11β‑HSD2 — producing mineralocorticoid effects and has been associated with adverse fetal/neonatal outcomes after maternal ingestion in epidemiological and animal studies; because this is a demonstrated endocrine mechanism it raises a suspected reproductive hazard for pregnancy when systemic exposure is possible. Sources: CIR final report (safety assessment covering disodium glycyrrhizate). Evidence of reproductive/foetal effects after oral licorice/glycyrrhizin exposure (epidemiology and animal studies). CosIng/EU ingredient listing supports cosmetic use but not a ban or restriction.
Hamilelikte disodium glycyrrhizate yerine kullanılabilecek güvenli alternatifler | VeriMom
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- disodium glycyrrhizate hamilelikte güvenli mi?
- No EU Annex II/III restriction or harmonised CLP classification for disodium glycyrrhizate was found, and CIR’s Final Report assessed disodium glycyrrhizate among licorice‑derived ingredients used in cosmetics and concluded safety in cosmetic use conditions. However, glycyrrhizic acid (parent molecule) has a demonstrated mechanism — inhibition of 11β‑HSD2 — producing mineralocorticoid effects and has been associated with adverse fetal/neonatal outcomes after maternal ingestion in epidemiological and animal studies; because this is a demonstrated endocrine mechanism it raises a suspected reproductive hazard for pregnancy when systemic exposure is possible. Sources: CIR final report (safety assessment covering disodium glycyrrhizate). Evidence of reproductive/foetal effects after oral licorice/glycyrrhizin exposure (epidemiology and animal studies). CosIng/EU ingredient listing supports cosmetic use but not a ban or restriction.
- disodium glycyrrhizate emzirirken güvenli mi?
- Mechanistic evidence (11β‑HSD2 inhibition by glycyrrhizic acid) is demonstrated and oral maternal intake of glycyrrhizin can lead to systemic effects; this supports a suspected hazard for breastfeeding if maternal systemic exposure is significant. Topical cosmetic use is expected to give low systemic absorption, so breastfeeding exposure from cosmetic topical use is likely low (measurable but small). CIR assessed cosmetic salts (including disodium glycyrrhizate) as safe as used; no harmonised CLP or EU ban/restriction was found.
- disodium glycyrrhizate bebek cildi için güvenli mi?
- No harmonised classification or EU ban/restriction for disodium glycyrrhizate; CIR concluded cosmetic use is acceptable. The parent molecule has a demonstrated mechanism (11β‑HSD2 inhibition), so a mechanistic flag exists. For topical use on infant skin, absorption is higher (immature barrier and higher surface‑area‑to‑weight) so exposure score is increased; however there is no direct infant dermal reproductive/toxicology data showing harm from cosmetic topical use. Therefore hazard is scored as 1 (class/mechanistic concern present but no direct dermal reproductive evidence for the cosmetic salt).
- VeriMom disodium glycyrrhizate nasıl puanlıyor?
- VeriMom disodium glycyrrhizate'yi EU CosIng, ECHA sınıflandırmaları ve PubMed çalışmalarına göre 40/100 (orta risk) olarak puanlar.
- Hamilelikte disodium glycyrrhizate yerine neler kullanılabilir?
- Benzer işlevli ve bilinen riski olmayan alternatifleri içeren listemize bakın.
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Tıbbi Sorumluluk Reddi
Bu bilgiler yalnızca eğitim amaçlıdır ve tıbbi tavsiye niteliği taşımaz. Güvenlik puanları kamuya açık verilere dayanmaktadır ve tüm riskleri yansıtmayabilir. Hamilelik veya emzirme döneminde herhangi bir ürünü kullanmadan önce her zaman sağlık uzmanınıza danışın.