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capryloyl salicylic acid hamilelikte güvenli mi?

Animal developmental data show effects at high doses (dermal application in pregnant rats: increased incomplete ossification at 100 mg/kg/day; NOAEL for developmental toxicity 40 mg/kg/day), so reproductive/developmental hazard is suspected based on animal evidence; there is no harmonised CLP reproductive classification and CIR concluded cosmetic use at reported concentrations is safe. Dermal absorption in vitro is low but measurable (~6% penetrated deeper than the stratum corneum in a 16 h Franz cell study), so exposure from typical topical cosmetic use is low but measurable.

İçerikler
capryloyl salicylic acid
ORTA RISK
53
/100
0

Pregnancy-safe products containing capryloyl salicylic acid

Hamilelikte capryloyl salicylic acid yerine kullanılabilecek güvenli alternatifler | VeriMom

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Frequently asked questions

capryloyl salicylic acid hamilelikte güvenli mi?
Animal developmental data show effects at high doses (dermal application in pregnant rats: increased incomplete ossification at 100 mg/kg/day; NOAEL for developmental toxicity 40 mg/kg/day), so reproductive/developmental hazard is suspected based on animal evidence; there is no harmonised CLP reproductive classification and CIR concluded cosmetic use at reported concentrations is safe. Dermal absorption in vitro is low but measurable (~6% penetrated deeper than the stratum corneum in a 16 h Franz cell study), so exposure from typical topical cosmetic use is low but measurable.
capryloyl salicylic acid emzirirken güvenli mi?
No direct data on excretion in milk were identified; because animal developmental effects exist (see pregnancy section) the ingredient is treated as a suspected reproductive/developmental hazard. Maternal topical exposure gives low but measurable dermal penetration (CIR data), so systemic exposure cannot be excluded though milk transfer data are absent.
capryloyl salicylic acid bebek cildi için güvenli mi?
Do not increase hazard without infant-specific evidence; however exposure score is increased by +1 for infants because CIR reports measurable dermal penetration in adults (~6% beyond stratum corneum and ~17% in stratum corneum by tape‑strip), and infant skin has higher absorption per weight. There are no infant-specific safety studies; CIR considered cosmetic uses (max reported leave‑on 0.5%) acceptable given available data.
VeriMom capryloyl salicylic acid nasıl puanlıyor?
VeriMom capryloyl salicylic acid'yi EU CosIng, ECHA sınıflandırmaları ve PubMed çalışmalarına göre 53/100 (orta risk) olarak puanlar.
Hamilelikte capryloyl salicylic acid yerine neler kullanılabilir?
Benzer işlevli ve bilinen riski olmayan alternatifleri içeren listemize bakın.

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Tıbbi Sorumluluk Reddi

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