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HIGH RISK

Hamilelikte estradiol kullanmaktan kaçınmalı mıyım? | VeriMom

Estradiol (17β‑estradiol, CAS 50-28-2) carries harmonised reproductive hazard classification (H360—may damage fertility or the unborn child) in EU classification sources and product SDSs, and medicinal product labeling/clinical guidance list estradiol as contraindicated in pregnancy. Estrogens cross the placenta and maternal/experimental studies show excess maternal estradiol alters fetal development. Topical/transdermal estradiol formulations are known to give systemic exposure, so topical cosmetic application with appreciable systemic absorption would expose the fetus. (ECHA classification/SDS; DailyMed drug labeling; animal and human studies).

ECHA regulatory hazard statements

  • H360
  • H360FD
  • H361
  • H362

What to use instead

Pregnancy-safe ingredients that serve a similar function:

FAQ

estradiol hamilelikte güvenli mi?
Estradiol (17β‑estradiol, CAS 50-28-2) carries harmonised reproductive hazard classification (H360—may damage fertility or the unborn child) in EU classification sources and product SDSs, and medicinal product labeling/clinical guidance list estradiol as contraindicated in pregnancy. Estrogens cross the placenta and maternal/experimental studies show excess maternal estradiol alters fetal development. Topical/transdermal estradiol formulations are known to give systemic exposure, so topical cosmetic application with appreciable systemic absorption would expose the fetus. (ECHA classification/SDS; DailyMed drug labeling; animal and human studies).
estradiol emzirirken güvenli mi?
Harmonised/label information and safety data sheets include H362 (may cause harm to breast‑fed children) and list lactation effects; clinical drug labels state estrogens are present in human milk and may reduce milk production and are contraindicated or advised against during breastfeeding. Estradiol is systemically bioactive and transfers into milk; topical/transdermal absorption can produce systemic levels. (ECHA/SDS; DailyMed; pharmacology literature).
estradiol bebek cildi için güvenli mi?
Hazard (H360/H362) is intrinsic to the parent hormone and applies to infants: estradiol is a potent estrogen with well‑characterized receptor activity and documented developmental effects in animal and human observational studies. Exposure via product applied to infant skin would be of high concern because estradiol is absorbable transdermally (used clinically as transdermal therapy) and infant skin has higher surface‑area‑to‑weight and immature barrier — exposure rating increased for infant skin. No infant‑safe cosmetic use is supported. (ECHA/SDS; clinical/transdermal product literature; peer‑reviewed studies on maternal estradiol effects).
VeriMom estradiol nasıl puanlıyor?
VeriMom estradiol'yi EU CosIng, ECHA sınıflandırmaları ve PubMed çalışmalarına göre 0/100 (yüksek risk) olarak puanlar.
Hamilelikte estradiol yerine neler kullanılabilir?
Benzer işlevli ve bilinen riski olmayan alternatifleri içeren listemize bakın.

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Tıbbi Sorumluluk Reddi

Bu bilgiler yalnızca eğitim amaçlıdır ve tıbbi tavsiye niteliği taşımaz. Güvenlik puanları kamuya açık verilere dayanmaktadır ve tüm riskleri yansıtmayabilir. Hamilelik veya emzirme döneminde herhangi bir ürünü kullanmadan önce her zaman sağlık uzmanınıza danışın.

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