VeriMomHamilelikte benzophenone-1 kullanmaktan kaçınmalı mıyım? | VeriMom
Benzophenone-1 (2,4-dihydroxybenzophenone; CAS 131-56-6) has a harmonised ECHA classification for reproductive toxicity H361 (suspected of damaging fertility or the unborn child), which justifies h=2. Peer-reviewed in vitro and mechanistic studies show endocrine activity (estrogenic activity in MCF‑7 cells and inhibition of steroidogenic enzymes including 17β‑HSD3), supporting a demonstrated mechanism (m=2). As a small lipophilic UV‑filter with documented biological activity and use in topical products, dermal uptake is plausible and judged moderate for pregnancy exposure (e=2). Sources: ECHA C&L / substance profile; SCCS activity on BP‑1; PubMed mechanistic studies; CIR review.
ECHA regulatory hazard statements
- •H361
What to use instead
Pregnancy-safe ingredients that serve a similar function:
FAQ
- benzophenone-1 hamilelikte güvenli mi?
- Benzophenone-1 (2,4-dihydroxybenzophenone; CAS 131-56-6) has a harmonised ECHA classification for reproductive toxicity H361 (suspected of damaging fertility or the unborn child), which justifies h=2. Peer-reviewed in vitro and mechanistic studies show endocrine activity (estrogenic activity in MCF‑7 cells and inhibition of steroidogenic enzymes including 17β‑HSD3), supporting a demonstrated mechanism (m=2). As a small lipophilic UV‑filter with documented biological activity and use in topical products, dermal uptake is plausible and judged moderate for pregnancy exposure (e=2). Sources: ECHA C&L / substance profile; SCCS activity on BP‑1; PubMed mechanistic studies; CIR review.
- benzophenone-1 emzirirken güvenli mi?
- Same hazard basis (ECHA harmonised H361) applies for lactation (h=2). Mechanistic data (in vitro estrogenic effects and inhibition of steroidogenic enzymes) indicate potential endocrine activity relevant to breast tissue and hormonal regulation (m=2). Exposure via systemic uptake from topical use is assessed as moderate (e=2), consistent with other benzophenone UV‑filters which show measurable absorption and systemic detection in biomonitoring studies (see cited literature).
- benzophenone-1 bebek cildi için güvenli mi?
- Hazard (h=2) and mechanistic (m=2) ratings follow the harmonised classification and the demonstrated endocrine activity. Exposure for infants (0–3 yr) is increased by one category compared with adults because immature/ thinner skin and higher surface‑area‑to‑weight ratio raise dermal uptake for ingredients with measurable absorption, so e=3. There is no infant‑specific evidence to increase h or m further.
- VeriMom benzophenone-1 nasıl puanlıyor?
- VeriMom benzophenone-1'yi EU CosIng, ECHA sınıflandırmaları ve PubMed çalışmalarına göre 13/100 (yüksek risk) olarak puanlar.
- Hamilelikte benzophenone-1 yerine neler kullanılabilir?
- Benzer işlevli ve bilinen riski olmayan alternatifleri içeren listemize bakın.
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