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Is nordihydroguaiaretic acid safe during pregnancy?

Reviewed by · Last reviewed

Pregnancy-Safe Ingredients Database — 28,000+ Ingredients Rated
nordihydroguaiaretic acid
NO KNOWN RISKS
93
/100
0

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Frequently asked questions

Is nordihydroguaiaretic acid safe during pregnancy?
No harmonised CLP reproductive classification (ECHA Annex VI) and no CIR or SCCS cosmetic safety opinion specifically flagging reproductive/teratogenic effects for nordihydroguaiaretic acid (NDGA). Search of PubMed shows limited and non-conclusive reproductive data; ECHA/PubChem entries report systemic toxicity concerns (e.g., hepatotoxicity) but not an H360/H361 reproductive classification. Topical use can give low but measurable dermal absorption for small lipophilic antioxidants, so exposure during pregnancy is rated low but measurable.
Is nordihydroguaiaretic acid safe while breastfeeding?
No regulatory harmonised reproductive/breastfeeding classification (ECHA Annex VI); no CIR/SCCS opinion identifying lactation transfer or milk-specific hazard. Given potential for low systemic absorption after topical use, low but measurable exposure to nursing parent is possible; no data demonstrating milk transfer were identified in the searched sources.
Is nordihydroguaiaretic acid safe for baby skin?
No evidence found of infant-specific reproductive or developmental toxicity in regulatory sources (no harmonised CLP reproto flags, no CIR/SCCS restrictions). Because infant skin has higher surface-area-to-weight and a less mature barrier, the exposure score is increased by +1 relative to adult topical exposure (adult e=1 → baby e=2). No infant-specific mechanistic data were identified.
How does VeriMom score nordihydroguaiaretic acid?
VeriMom scores nordihydroguaiaretic acid at 93/100 (no known risks) based on EU CosIng status, ECHA hazard classifications, and peer-reviewed PubMed studies. Our scoring pipeline is fully transparent.
What are pregnancy-safe alternatives to nordihydroguaiaretic acid?
See our curated list of pregnancy-safe alternatives to nordihydroguaiaretic acid based on similar function and a no-known-risks safety band.

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Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice. Safety scores are based on publicly available data and may not reflect all risks. Always consult your healthcare provider before using any product during pregnancy or breastfeeding.

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