VeriMompaeonol é seguro durante a gravidez?
No EU Annex II/III listing or harmonised reproductive (H360/H361) classification was found for paeonol (ECHA substance page). The CIR safety assessment of Paeonia-derived ingredients (which identifies paeonol as a major constituent) did not identify reproductive/developmental hazards and concluded data were insufficient to make safety determinations for most extracts rather than finding a reproductive hazard (CIR, Dec 13, 2024). Limited animal/experimental reports show tissue distribution to uterus after oral dosing in mice but do not demonstrate developmental toxicity (PubMed). Therefore hazard (h) is 0; a low but measurable topical absorption is plausible so exposure (e) is 1. Sources: https://www.cir-safety.org/sites/default/files/TR_PaeoniaSuffruticosa_122024.pdf, https://pubmed.ncbi.nlm.nih.gov/32058234/, https://echa.europa.eu/substance-information/-/substanceinfo/100.008.194
Pregnancy-safe products containing paeonol
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Frequently asked questions
- paeonol é seguro durante a gravidez?
- No EU Annex II/III listing or harmonised reproductive (H360/H361) classification was found for paeonol (ECHA substance page). The CIR safety assessment of Paeonia-derived ingredients (which identifies paeonol as a major constituent) did not identify reproductive/developmental hazards and concluded data were insufficient to make safety determinations for most extracts rather than finding a reproductive hazard (CIR, Dec 13, 2024). Limited animal/experimental reports show tissue distribution to uterus after oral dosing in mice but do not demonstrate developmental toxicity (PubMed). Therefore hazard (h) is 0; a low but measurable topical absorption is plausible so exposure (e) is 1. Sources: https://www.cir-safety.org/sites/default/files/TR_PaeoniaSuffruticosa_122024.pdf, https://pubmed.ncbi.nlm.nih.gov/32058234/, https://echa.europa.eu/substance-information/-/substanceinfo/100.008.194
- paeonol é seguro durante a amamentação?
- No data were located indicating paeonol is a known lactation teratogen or has harmonised reproductive/lactation classification (ECHA; CIR). There are reports that whole peony preparations can affect prolactin, but these refer to other peony constituents (paeoniflorin) and not paeonol specifically (LactMed/peony summaries). Given limited systemic exposure from typical topical cosmetic use, exposure via milk is expected to be low but measurable (h=0, e=1). Sources: https://www.cir-safety.org/sites/default/files/TR_PaeoniaSuffruticosa_122024.pdf, https://www.ncbi.nlm.nih.gov/books/NBK501902/, https://echa.europa.eu/substance-information/-/substanceinfo/100.008.194
- paeonol é seguro para a pele do bebê?
- No evidence specific to infants (0–3 yr) shows developmental or reproductive hazard for paeonol and no harmonised CMR classification exists (ECHA; CIR). However, because paeonol is a small phenolic molecule used topically and dermal absorption is plausible, infant exposure is higher due to immature barrier and higher surface-area-to-weight; per scoring rules exposure is increased by +1 (adult e=1 → baby e=2). No infant-specific mechanistic evidence was found. Sources: https://www.cir-safety.org/sites/default/files/TR_PaeoniaSuffruticosa_122024.pdf, https://echa.europa.eu/substance-information/-/substanceinfo/100.008.194, https://pubmed.ncbi.nlm.nih.gov/32058234/
- Como o VeriMom pontua paeonol?
- O VeriMom pontua paeonol em 93/100 (sem riscos conhecidos) com base no status EU CosIng, classificações de perigo ECHA e estudos revisados por pares no PubMed. Nosso pipeline de pontuação é totalmente transparente.
- Quais são as alternativas seguras a paeonol na gravidez?
- Veja nossa lista curada de alternativas seguras a paeonol com base em função semelhante e classificação sem riscos conhecidos.
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Aviso Médico
Estas informações são apenas para fins educacionais e não constituem aconselhamento médico. As pontuações de segurança são baseadas em dados publicamente disponíveis e podem não refletir todos os riscos. Sempre consulte seu profissional de saúde antes de usar qualquer produto durante a gravidez ou amamentação.