Devo evitar plectranthus barbatus root extract na gravidez? | VeriMom

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FAQ

plectranthus barbatus root extract é seguro durante a gravidez?

No EU cosmetic ban/restriction was found for Plectranthus/Coleus (INCI listed in the EU Official Journal), but the root extract contains forskolin. Forskolin has been shown to induce endocrine disturbances in human placental JEG‑3 cells (in vitro) and an older rat study reported anti‑implantation/delayed fetal effects — therefore reproductive hazard is “suspected” (h=2) with a demonstrated mechanism (m=2). An in vitro skin diffusion study showed forskolin can permeate human skin and permeation is enhanced when delivered in the crude P. barbatus root extract, so topical exposure is measurable/moderate (e=2). Sources: EU CosIng/Official Journal; in vitro placental study (PMCID: PMC9317975); in vitro skin diffusion J Nat Prod (Chen et al.).

plectranthus barbatus root extract é seguro durante a amamentação?

There are no reliable human milk/excretion studies for Plectranthus/forskolin; guidance resources warn against oral use in pregnancy/lactation due to limited safety data. Because systemic exposure to forskolin could theoretically affect nursing infants but direct evidence for adverse effects via breastmilk is lacking, assign a low/class‑based concern (h=1) with a theoretical mechanism (m=1). Topical cosmetic use has low but measurable systemic absorption potential (e=1). Sources: LactMed/NCBI Monograph; WebMD summary; PMC placental study (mechanistic relevance).

plectranthus barbatus root extract é seguro para a pele do bebê?

No infant‑specific adverse dermatologic or developmental data were found for topical Plectranthus barbatus root extract. Per instructions, baby hazard (h) and mechanism (m) were not increased in the absence of infant‑specific evidence. However, because the extract (and forskolin within it) shows measurable skin permeation in vitro and infant skin has higher surface‑area‑to‑weight and immature barrier, exposure is increased for babies (+1 vs adult), giving e=3. Sources: J Nat Prod skin diffusion study; no baby‑specific safety studies located.

Como o VeriMom pontua plectranthus barbatus root extract?

O VeriMom pontua plectranthus barbatus root extract em 33/100 (risco alto) com base no status EU CosIng, classificações de perigo ECHA e estudos revisados por pares no PubMed. Nosso pipeline de pontuação é totalmente transparente.

Quais são as alternativas seguras a plectranthus barbatus root extract na gravidez?

Veja nossa lista curada de alternativas seguras a plectranthus barbatus root extract com base em função semelhante e classificação sem riscos conhecidos.