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Devo evitar m-phenylenediamine na gravidez? | VeriMom

CIR’s safety review (1997 summary) reports one animal study with fetal deaths (other studies negative) and identifies measurable percutaneous absorption and metabolites — this supports a “suspected” reproductive hazard (h=2) rather than confirmed teratogen. No well‑characterised reproductive mechanism was found, only limited mechanistic data (hence m=1). Dermal absorption from hair‑dye use is reported as low but measurable, so exposure from typical topical cosmetic use is scored e=1. (Sources: CIR summary/CosmeticsInfo; PubMed animal study; ECHA registration dossier.)

ECHA regulatory hazard statements

  • H341
  • H331
  • H311
  • H301
  • H319
  • H317
  • H400
  • H410

What to use instead

Pregnancy-safe ingredients that serve a similar function:

FAQ

m-phenylenediamine é seguro durante a gravidez?
CIR’s safety review (1997 summary) reports one animal study with fetal deaths (other studies negative) and identifies measurable percutaneous absorption and metabolites — this supports a “suspected” reproductive hazard (h=2) rather than confirmed teratogen. No well‑characterised reproductive mechanism was found, only limited mechanistic data (hence m=1). Dermal absorption from hair‑dye use is reported as low but measurable, so exposure from typical topical cosmetic use is scored e=1. (Sources: CIR summary/CosmeticsInfo; PubMed animal study; ECHA registration dossier.)
m-phenylenediamine é seguro durante a amamentação?
There are no robust human breastfeeding studies identified. The same animal evidence (fetal death in at least one study) and CIR finding of measurable dermal absorption support a conservative ‘suspected’ hazard for reproductive/developmental endpoints (h=2) and a theoretical mechanism only (m=1). Dermal exposure during use (hair dyes) is low but measurable (e=1); transfer into breastmilk was not specifically documented in available sources. (Sources: CIR summary/CosmeticsInfo; PubMed study; ECHA dossier.)
m-phenylenediamine é seguro para a pele do bebê?
Hazard (h) and mechanism (m) are unchanged because no infant‑specific reproductive mechanism data were found. Adult dermal absorption is measurable; per instructions, increase exposure score by +1 for 0–3‑year‑old skin when absorption is measurable — adult e=1 → baby e=2. No infant‑specific dermal absorption or toxicokinetic studies were located. (Sources: CIR summary/CosmeticsInfo; ECHA registration; guidance on absorption in CIR review.)
Como o VeriMom pontua m-phenylenediamine?
O VeriMom pontua m-phenylenediamine em 27/100 (risco alto) com base no status EU CosIng, classificações de perigo ECHA e estudos revisados por pares no PubMed. Nosso pipeline de pontuação é totalmente transparente.
Quais são as alternativas seguras a m-phenylenediamine na gravidez?
Veja nossa lista curada de alternativas seguras a m-phenylenediamine com base em função semelhante e classificação sem riscos conhecidos.

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Aviso Médico

Estas informações são apenas para fins educacionais e não constituem aconselhamento médico. As pontuações de segurança são baseadas em dados publicamente disponíveis e podem não refletir todos os riscos. Sempre consulte seu profissional de saúde antes de usar qualquer produto durante a gravidez ou amamentação.

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