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dioscorea oppositifolia root extract은 임신 중 안전한가요?

No harmonised CLP reproductive classification (ECHA Annex VI) or CIR/SCCS safety assessment specific to Dioscorea oppositifolia root extract was found, and regulatory sources do not flag it as a reproductive teratogen — so default hazard = 0. However, the presence of steroidal sapogenins such as diosgenin in Dioscorea species provides a theoretical structural/class-based concern for endocrine activity based on in vitro/chemical similarity data (PubMed), so mechanism = 1. For typical topical cosmetic use, systemic exposure is expected to be low but measurable, so exposure = 1.

성분
dioscorea oppositifolia root extract
낮은 위험
87
/100
0

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dioscorea oppositifolia root extract은 임신 중 안전한가요?
No harmonised CLP reproductive classification (ECHA Annex VI) or CIR/SCCS safety assessment specific to Dioscorea oppositifolia root extract was found, and regulatory sources do not flag it as a reproductive teratogen — so default hazard = 0. However, the presence of steroidal sapogenins such as diosgenin in Dioscorea species provides a theoretical structural/class-based concern for endocrine activity based on in vitro/chemical similarity data (PubMed), so mechanism = 1. For typical topical cosmetic use, systemic exposure is expected to be low but measurable, so exposure = 1.
dioscorea oppositifolia root extract은 모유 수유 중 안전한가요?
No authoritative reports (ECHA Annex VI, CIR, SCCS) identify lactation or breastmilk transfer hazards for this extract, so hazard = 0. Theoretical endocrine-related mechanism from diosgenin-containing extracts supports a low-level mechanistic concern (m=1). Topical use would likely result in low maternal systemic exposure and therefore low risk of transfer to breastmilk (e=1).
dioscorea oppositifolia root extract은 아기 피부에 안전한가요?
There is no evidence of infant-specific reproductive or developmental toxicity in authoritative sources for this extract (h=0). Mechanistic/theoretical concerns about steroidal saponins remain (m=1) but are not demonstrated in vivo. Because infant skin has higher per-body-weight absorption, exposure is increased by +1 relative to adults (adult e=1 → baby e=2), making dermal exposure potentially more relevant for 0–3 yr olds.
VeriMom은 dioscorea oppositifolia root extract을 어떻게 평가하나요?
VeriMom은 EU CosIng, ECHA 분류, PubMed 연구를 기반으로 dioscorea oppositifolia root extract을 87/100 (낮은 위험)로 평가합니다.
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