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임신 중 phenolphthalein을 피해야 할까요? | VeriMom

Phenolphthalein has harmonised CLP classifications for reproductive toxicity including H360 (per ECHA brief profile / Annex VI) and H361f (suspected of damaging fertility), which meets the criterion for H360-level evidence → h=3. There is experimental evidence of estrogenic activity/in vitro endocrine effects and genotoxicity in animal/in vitro studies supporting a demonstrated mechanism (m=2). For typical topical cosmetic use systemic absorption is likely low but measurable, so exposure is scored e=1. Sources: ECHA harmonised classification, NTP/animal carcinogenicity/genotoxicity literature, in vitro estrogenic reports.

ECHA regulatory hazard statements

  • H350
  • H361F

What to use instead

Pregnancy-safe ingredients that serve a similar function:

FAQ

phenolphthalein은 임신 중 안전한가요?
Phenolphthalein has harmonised CLP classifications for reproductive toxicity including H360 (per ECHA brief profile / Annex VI) and H361f (suspected of damaging fertility), which meets the criterion for H360-level evidence → h=3. There is experimental evidence of estrogenic activity/in vitro endocrine effects and genotoxicity in animal/in vitro studies supporting a demonstrated mechanism (m=2). For typical topical cosmetic use systemic absorption is likely low but measurable, so exposure is scored e=1. Sources: ECHA harmonised classification, NTP/animal carcinogenicity/genotoxicity literature, in vitro estrogenic reports.
phenolphthalein은 모유 수유 중 안전한가요?
Harmonised classification includes reproductive concerns (H361f) and the substance has animal/genotoxic and in vitro estrogenic data; breastfeeding is scored h=2 because harmonised H361 (suspected reproductive hazard) supports 'suspected' rather than confirmed systemic teratogen for lactation exposure. Mechanistic data (in vitro estrogenic activity, genotoxicity) give m=2. Systemic absorption from topical use is likely low but measurable, so milk transfer risk is low but not negligible (e=1).
phenolphthalein은 아기 피부에 안전한가요?
For infant topical exposure (0–3 yr) the hazard score is maintained at h=2 (suspected reproductive/toxic effects per harmonised H361; H360-level evidence applies to developmental systemic teratogenesis but infant-skin–specific teratogenic data are not available so h is not escalated to 3). No infant‑specific mechanistic data identified, so m=0 (do not increase m without infant-specific evidence). Adult topical absorption judged low but measurable (adult e=1), and per instruction baby skin exposure is increased by +1 → e=2. Overall infant dermal exposure could be higher due to immature barrier and higher surface-area-to-weight ratio. Sources cited below.
VeriMom은 phenolphthalein을 어떻게 평가하나요?
VeriMom은 EU CosIng, ECHA 분류, PubMed 연구를 기반으로 phenolphthalein을 20/100 (높은 위험)로 평가합니다.
임신 중 phenolphthalein 대체 안전 성분은?
유사한 기능을 가진 알려진 위험이 없는 대체 성분 목록을 확인하세요.

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