임신 중 methotrexate을 피해야 할까요? | VeriMom

What to use instead

Pregnancy-safe ingredients that serve a similar function:

FAQ

methotrexate은 임신 중 안전한가요?

Methotrexate is a well‑known human teratogen and is contraindicated in pregnancy (FDA labeling: Pregnancy Category X) and causes fetal harm via folate antagonism (dihydrofolate reductase inhibition) with documented fetal malformations and pregnancy loss; this is a harmonised/high‑level reproductive hazard. Topical cosmetic use would give negligible systemic exposure in routine cosmetic scenarios, so exposure from cosmetic use is expected to be negligible. (Sources: FDA label; peer‑reviewed teratology literature; regulatory listings).

methotrexate은 모유 수유 중 안전한가요?

Methotrexate is contraindicated in nursing mothers in drug labeling because of potential for serious adverse effects in the breastfed infant and its systemic distribution; mechanism (DHFR inhibition/antifolate) is established. For a cosmetic topical use scenario, maternal systemic exposure from a cosmetic product would be negligible, so milk transfer from cosmetic use is not expected.

methotrexate은 아기 피부에 안전한가요?

Hazard is high (harmonised/regulatory teratogen/antimetabolite). For direct application to baby (0–3 yr) the immature barrier raises exposure compared with adults: even if adult topical absorption is negligible for a highly polar drug, the guidance requires raising the exposure score by +1 for baby skin when measurable absorption is possible. Therefore exposure = 1 for baby skin; mechanism (antifolate/DHFR inhibition) is well characterized.

VeriMom은 methotrexate을 어떻게 평가하나요?

VeriMom은 EU CosIng, ECHA 분류, PubMed 연구를 기반으로 methotrexate을 20/100 (높은 위험)로 평가합니다.

임신 중 methotrexate 대체 안전 성분은?

유사한 기능을 가진 알려진 위험이 없는 대체 성분 목록을 확인하세요.