VeriMomShould I Avoid retinyl dimethylglycylprolinate During Pregnancy? | VeriMom
No EU Annex II/III listing or harmonised CLP (no H360/H361) was found for this specific ingredient; however it is a retinyl (vitamin A) derivative and therefore carries a class-based structural concern (SCCS has explicit limits for retinol/retinyl esters in cosmetics). No published reproductive/teratogenic animal or human data specific to retinyl dimethylglycylprolinate were located. Sources: SCCS vitamin A opinion (class-level restriction), DSM Revitalin product note, CosIng ingredient listings. (SCCS limits indicate class concern but do not equate to harmonised CMR classification).
What to use instead
Pregnancy-safe ingredients that serve a similar function:
FAQ
- Is retinyl dimethylglycylprolinate safe during pregnancy?
- No EU Annex II/III listing or harmonised CLP (no H360/H361) was found for this specific ingredient; however it is a retinyl (vitamin A) derivative and therefore carries a class-based structural concern (SCCS has explicit limits for retinol/retinyl esters in cosmetics). No published reproductive/teratogenic animal or human data specific to retinyl dimethylglycylprolinate were located. Sources: SCCS vitamin A opinion (class-level restriction), DSM Revitalin product note, CosIng ingredient listings. (SCCS limits indicate class concern but do not equate to harmonised CMR classification).
- Is retinyl dimethylglycylprolinate safe while breastfeeding?
- Same rationale as pregnancy: class-based concern because this is a retinyl derivative; no ingredient-specific lactation/breastmilk transfer data located. Topical retinyl esters are generally considered to give low systemic dose under recommended uses per SCCS, but absence of data for this specific derivative creates uncertainty.
- Is retinyl dimethylglycylprolinate safe for baby skin?
- No infant-specific toxicity or developmental studies were found for this ingredient. Because baby skin has higher absorption, exposure score for babies is increased by +1 (per your rules). No evidence was found that the ingredient is banned or harmonised as a reproductive toxicant; nevertheless the retinyl class structural concern remains and SCCS restrictions for vitamin A in cosmetics are relevant for infant exposure mitigation.
- How does VeriMom score retinyl dimethylglycylprolinate?
- VeriMom scores retinyl dimethylglycylprolinate at 13/100 (high risk) based on EU CosIng status, ECHA hazard classifications, and peer-reviewed PubMed studies. Our scoring pipeline is fully transparent.
- What are pregnancy-safe alternatives to retinyl dimethylglycylprolinate?
- See our curated list of pregnancy-safe alternatives to retinyl dimethylglycylprolinate based on similar function and a no-known-risks safety band.
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Medical Disclaimer
This information is for educational purposes only and does not constitute medical advice. Safety scores are based on publicly available data and may not reflect all risks. Always consult your healthcare provider before using any product during pregnancy or breastfeeding.