VeriMomHamilelikte plectranthus barbatus root extract kullanmaktan kaçınmalı mıyım? | VeriMom
No EU cosmetic ban/restriction was found for Plectranthus/Coleus (INCI listed in the EU Official Journal), but the root extract contains forskolin. Forskolin has been shown to induce endocrine disturbances in human placental JEG‑3 cells (in vitro) and an older rat study reported anti‑implantation/delayed fetal effects — therefore reproductive hazard is “suspected” (h=2) with a demonstrated mechanism (m=2). An in vitro skin diffusion study showed forskolin can permeate human skin and permeation is enhanced when delivered in the crude P. barbatus root extract, so topical exposure is measurable/moderate (e=2). Sources: EU CosIng/Official Journal; in vitro placental study (PMCID: PMC9317975); in vitro skin diffusion J Nat Prod (Chen et al.).
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FAQ
- plectranthus barbatus root extract hamilelikte güvenli mi?
- No EU cosmetic ban/restriction was found for Plectranthus/Coleus (INCI listed in the EU Official Journal), but the root extract contains forskolin. Forskolin has been shown to induce endocrine disturbances in human placental JEG‑3 cells (in vitro) and an older rat study reported anti‑implantation/delayed fetal effects — therefore reproductive hazard is “suspected” (h=2) with a demonstrated mechanism (m=2). An in vitro skin diffusion study showed forskolin can permeate human skin and permeation is enhanced when delivered in the crude P. barbatus root extract, so topical exposure is measurable/moderate (e=2). Sources: EU CosIng/Official Journal; in vitro placental study (PMCID: PMC9317975); in vitro skin diffusion J Nat Prod (Chen et al.).
- plectranthus barbatus root extract emzirirken güvenli mi?
- There are no reliable human milk/excretion studies for Plectranthus/forskolin; guidance resources warn against oral use in pregnancy/lactation due to limited safety data. Because systemic exposure to forskolin could theoretically affect nursing infants but direct evidence for adverse effects via breastmilk is lacking, assign a low/class‑based concern (h=1) with a theoretical mechanism (m=1). Topical cosmetic use has low but measurable systemic absorption potential (e=1). Sources: LactMed/NCBI Monograph; WebMD summary; PMC placental study (mechanistic relevance).
- plectranthus barbatus root extract bebek cildi için güvenli mi?
- No infant‑specific adverse dermatologic or developmental data were found for topical Plectranthus barbatus root extract. Per instructions, baby hazard (h) and mechanism (m) were not increased in the absence of infant‑specific evidence. However, because the extract (and forskolin within it) shows measurable skin permeation in vitro and infant skin has higher surface‑area‑to‑weight and immature barrier, exposure is increased for babies (+1 vs adult), giving e=3. Sources: J Nat Prod skin diffusion study; no baby‑specific safety studies located.
- VeriMom plectranthus barbatus root extract nasıl puanlıyor?
- VeriMom plectranthus barbatus root extract'yi EU CosIng, ECHA sınıflandırmaları ve PubMed çalışmalarına göre 33/100 (yüksek risk) olarak puanlar.
- Hamilelikte plectranthus barbatus root extract yerine neler kullanılabilir?
- Benzer işlevli ve bilinen riski olmayan alternatifleri içeren listemize bakın.
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Bu bilgiler yalnızca eğitim amaçlıdır ve tıbbi tavsiye niteliği taşımaz. Güvenlik puanları kamuya açık verilere dayanmaktadır ve tüm riskleri yansıtmayabilir. Hamilelik veya emzirme döneminde herhangi bir ürünü kullanmadan önce her zaman sağlık uzmanınıza danışın.