VeriMomHIGH RISK
Should I Avoid methoxydiglycol During Pregnancy? | VeriMom
Reviewed by VeriMom Editorial Team · Last reviewed
ECHA regulatory hazard statements
- •H360D
What to use instead
Pregnancy-safe ingredients that serve a similar function:
Pregnancy-safe products to use instead
Products built around the safer ingredients above, scored "no known risks" or "low risk".
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Sources & references
Authoritative references used to score this ingredient.
Pregnancy-Safe Alternatives to methoxydiglycol | VeriMom
Ingredients — Pregnancy-Safe Ingredients Database — 28,000+ Ingredients Rated
See also
FAQ
- Is methoxydiglycol safe during pregnancy?
- ECHA lists diethylene glycol monomethyl ether (methoxydiglycol, CAS 111-77-3) with a harmonised CLP classification for reproductive toxicity (H360 - may damage fertility or the unborn child), which places it in the highest hazard band for developmental/reproductive effects. Animal and mechanistic work show it is metabolised to methoxyacetic acid, a metabolite implicated in reproductive/developmental toxicity in multiple studies, supporting a demonstrated mechanism. Dermal/topical use gives measurable systemic absorption for small glycols used as solvents, so exposure from cosmetics is non‑negligible (moderate). ([echa.europa.eu](https://echa.europa.eu/et/brief-profile/-/briefprofile/100.003.551?utm_source=openai))
- Is methoxydiglycol safe while breastfeeding?
- Because the substance has a harmonised H360 reproductive classification and is metabolised to methoxyacetic acid (a known reproductive toxicant), there is concern for transfer to nursing infants; advisory bodies note uncertainty but flag lactation as a relevant route and the absence of data on milk levels. Dermal/topical use can produce systemic levels (measurable), so breastfeeding exposure cannot be ruled out. ([echa.europa.eu](https://echa.europa.eu/et/brief-profile/-/briefprofile/100.003.551?utm_source=openai))
- Is methoxydiglycol safe for baby skin?
- Hazard (H360) remains highest (h=3) due to harmonised CLP classification and animal evidence. Mechanistic concern (metabolism to methoxyacetic acid) is demonstrated. Exposure (e) is increased by +1 for infants (per your instruction): because the compound is a small, moderately skin‑permeable solvent with measurable dermal uptake in adults, infant skin (higher SA:weight and immature barrier) raises likely systemic exposure to high. ([echa.europa.eu](https://echa.europa.eu/et/brief-profile/-/briefprofile/100.003.551?utm_source=openai))
- How does VeriMom score methoxydiglycol?
- VeriMom scores methoxydiglycol at 13/100 (high risk) based on EU CosIng status, ECHA hazard classifications, and peer-reviewed PubMed studies. Our scoring pipeline is fully transparent.
- What are pregnancy-safe alternatives to methoxydiglycol?
- See our curated list of pregnancy-safe alternatives to methoxydiglycol based on similar function and a no-known-risks safety band.
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Medical Disclaimer
This information is for educational purposes only and does not constitute medical advice. Safety scores are based on publicly available data and may not reflect all risks. Always consult your healthcare provider before using any product during pregnancy or breastfeeding.