VeriMomHamilelikte cis-retinoic acid kullanmaktan kaçınmalı mıyım? | VeriMom
13‑cis‑retinoic acid (isotretinoin, CAS 4759‑48‑2) is a well‑established human teratogen when given systemically (oral isotretinoin causes severe, characteristic birth defects) and is regulated as a pregnancy‑contraindicated retinoid; the teratogenic mechanism is well characterized via retinoic‑acid / retinoid receptor signalling. Topical use gives lower systemic exposure than oral dosing but measurable absorption has been reported for topical retinoids and regulatory guidance treats retinoic acid/isotretinoin as a pregnancy risk. ([fda.gov](https://www.fda.gov/media/166611/download?utm_source=openai))
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FAQ
- cis-retinoic acid hamilelikte güvenli mi?
- 13‑cis‑retinoic acid (isotretinoin, CAS 4759‑48‑2) is a well‑established human teratogen when given systemically (oral isotretinoin causes severe, characteristic birth defects) and is regulated as a pregnancy‑contraindicated retinoid; the teratogenic mechanism is well characterized via retinoic‑acid / retinoid receptor signalling. Topical use gives lower systemic exposure than oral dosing but measurable absorption has been reported for topical retinoids and regulatory guidance treats retinoic acid/isotretinoin as a pregnancy risk. ([fda.gov](https://www.fda.gov/media/166611/download?utm_source=openai))
- cis-retinoic acid emzirirken güvenli mi?
- Oral isotretinoin is contraindicated in breastfeeding because of concern for systemic exposure to the infant; the biological mechanism (retinoid receptor activity) is the same as for pregnancy. For topical cosmetic use, systemic transfer into milk is expected to be low but not zero, so breastfeeding exposure is considered low but not negligible. ([fda.gov](https://www.fda.gov/media/166611/download?utm_source=openai))
- cis-retinoic acid bebek cildi için güvenli mi?
- There is no infant‑specific evidence that topical cis‑retinoic acid applied to baby skin produces developmental/teratogenic effects (do not upgrade h/m without direct data). However infant skin has higher absorption (immature barrier and higher surface‑area‑to‑weight), so exposure scoring is increased relative to adults if the ingredient is present or applied directly. Topical retinoids are generally discouraged on young children because of irritancy and potential systemic uptake. ([pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/32643315/?utm_source=openai))
- VeriMom cis-retinoic acid nasıl puanlıyor?
- VeriMom cis-retinoic acid'yi EU CosIng, ECHA sınıflandırmaları ve PubMed çalışmalarına göre 7/100 (yüksek risk) olarak puanlar.
- Hamilelikte cis-retinoic acid yerine neler kullanılabilir?
- Benzer işlevli ve bilinen riski olmayan alternatifleri içeren listemize bakın.
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Tıbbi Sorumluluk Reddi
Bu bilgiler yalnızca eğitim amaçlıdır ve tıbbi tavsiye niteliği taşımaz. Güvenlik puanları kamuya açık verilere dayanmaktadır ve tüm riskleri yansıtmayabilir. Hamilelik veya emzirme döneminde herhangi bir ürünü kullanmadan önce her zaman sağlık uzmanınıza danışın.